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PHYTOCHEMICAL INVESTIGATION AND PHARMACOLOGICAL EVALUATION OF LEAVES OF ZIZIPHUS MAURITIANA FOR WOUND HEALING ACTIVITY IN ALBINO RATS
Various medicinal plants are used in traditional system of medicine to treat various diseases and many of these plants have been evaluated for their different pharmacological activities Ziziphus mauritiana one of them. The present work deals with the study of ethanolic extract of leaves of ziziphus mauritiana for its wound healing potency. An excision wound was inflicted by cutting away a 500 mm2 full thickness of skin from a predetermined area an impression was made on the dorsal thoracic region 1cm away from vertebral column and 5cm away from ear on the anaesthetized Rats. Wound contraction was measured as percentage contraction in each 2 days after wound formation from the healed wound. The wound healing was evaluated by using two different models viz. full thickness excision and dead space wound models. The reading were recorded on 1,3,5,7,9,11,13,15,17 and 19th day after post wound day. The ZMLE and standard drug were applied daily to the wound area daily. The healing was assessed by physical parameters like percentage wound contraction, epithelisation and determination of hydroxyproline. The treatment with the ZMLE produced the anti-inflammatory activity against excision wound model and dead space wound model. The ZMLE showed anti-inflammatory activity against Excision wound when compared to the standard cipladine (povidine iodine 5%w/w). There were significant reduction in days required to healing and hydroxyproline and weight of wet and dry granuloma tissue were increased significantly by the treatment with ZMLE. Healing of excision wound were promoted significantly by treatment with ZMLE, ZMLE promoted the wound contraction and reduced the days required for epithelisation. ZMLE possesses significant anti-inflammatory and wound healing properties.
SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF BENIDIPINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION
The present study was aimed to develop a novel simple, accurate, precise, robust and economic UV-spectrophotometric method for estimation of benidipine hydrochloride in pharmaceutical formulation. The developed method was validated with accordance to ICH Q2 (R1) guidelines. Beer’s law was obeyed in the concentration range 1-3.5µg/mL with correlation coefficient of 0.9938. The sensitivity was checked as the limit of detection and limit of quantitation which were found to be 0.04540 and 0.1375µg/mL respectively. A further study of the accuracy of the proposed method was performed using standard addition method. It can be concluded that the developed method was specific, selective, precise and robust. This method could be successfully applied for analysis of benidipine hydrochloride in its pharmaceutical formulation.
DESIGN, SYNTHESIS AND SCREENING OF BENZOXAZOLE DERIVATIVES FOR ANTIHYPERGLYCAEMIC ACTIVITY
Benzoxazole nucleus containing heterocyclic compounds plays an important role in medicinal chemistry and exhibit wide range of biological activities such as antihyperglycaemic, antidepressant, antibacterial, antifungal, antiinflammatory, antispasmodic, antiallergic and antiasthemetic activity. The present study describes the design, synthesis and in vivo testing of new series of benzoxazole derivatives as antihyperglycaemic agents in alloxan induced diabetic Wistar albino rats pioglitazone used as a standard drug. Most of the compounds showed significant antihyperglycaemic activity when compared with the standard drug pioglitazone. The structures of all synthesized compounds were determined by their IR, 1H NMR and MASS spectral analysis.
AN OVERVIEW ON OPPORTUNITY OF MEDICAL TOURISM IN INDIA
Medical Tourism business in India is emergent and world of sunshine for those patients who are global trotter and wants their treatment at affordable cost but of high quality. it has enormous prospective for generating jobs and earning huge sum of foreign exchange besides giving a spur to the country’s overall monetary growth. Medical tourism is a multi-facet bustle, and basically a service industry, it would be essential that all spheres of the Central and State governments, private sector and voluntary organizations become dynamic partners in the enterprise to attain sustainable expansion in tourism if India is to become a global player in the medical tourism business. The emergence and growth of foreign-oriented medical services; the creation of “hotel-spitals” business-like hospitals, combining high-class medical and hospitality services for a foreign clientele. The medical tourism business offers soaring prospective for India primarily because of its natural advantages in terms of charge and quality. However the competition is getting intense and the accomplishment in upcoming years will mostly be determined by growth and implementation of a joint approach by various parties in the industry. Medical tourism is highly pretentious to hospitals, travelers, hotels, insurance companies etc. Most common treatments are cardio-vascular surgery, knee transplant, cosmetic surgery, cataract, dental care, hair transplants, liver and kidney transplant. The cause India is a favorable destination is because of its infrastructure and state-of-the-art-technology in which is in par with developed countries. India has some of the best hospitals, healthcare and treatment centers in the world with the best facilities.