Science
Articles in this Issue
Ice as a geochemical reactor
Freezing redirects the fate of iron in Earth’s cryosphere
Does AI work for us, or do we work for AI? <b>The Reverse Centaur’s Guide to Life After AI</b> <i>Cory Doctorow</i> MCD, 2026. 240 pp.
There is little enthusiasm for a technology that turns human users into “reverse centaurs,” argues a critic
To eat or to breathe?
In highland mice, the responses to low oxygen and toxins compete for a shared molecular regulator
The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity
The cancer-immunity cycle requires cross-presenting type I conventional dendritic cells (cDC1s) that induce T cell–mediated immunity, but therapeutic strategies for enhancing intratumoral cDC1 functio...
Why cities cannot learn
For most of the world’s urban history, changes in policies and responses to hazards have proceeded on a timescale that made adaptation possible, however slow or politically contested. The Great Fire o...
Laser phase plate improves structure determination of small proteins by cryo-EM
Phase plates can, in principle, overcome the poor image contrast in cryo–electron microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous de...
US military expansion and deep-sea mining pose environmental risks to Guam
As bird flu threatens, New Zealand vaccinates endangered birds
Arrival of H5N1 virus on Australian mainland triggers ambitious vaccination program
Bridging data gaps to support the Global Plastics Treaty
Reporting should consider data harmonization, supply chain metrics, and pollution hotspot identification
Long-range extended chains arising from polymerization-driven spontaneous assembly
A central challenge for conjugated polymers is to achieve long-range order while remaining solution processable, which is essential for matching the electrical performance of their counterparts of cry...
EU horse legislation compromises ecosystem restoration efforts
Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues
Lysine acetyltransferases (KATs) cooperate with oncogenes such as c-Myc, estrogen receptor, and lysine methyltransferase 2A (KMT2A) fusions to sustain malignant programs. Targeting of KAT proteins has...