Nature
Articles in this Issue
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease
Abstract Protein misfolding diseases, including α1-antitrypsin deficiency (AATD), pose substantial health challenges, with their cellular progression still poorly understood1–3. We use spati...
Lipid-degrading small molecule kills cancer cells by ferroptosis
The phased pan-genome of tetraploid European potato
Abstract Potatoes were first brought to Europe in the sixteenth century1,2. Two hundred years later, one of the species had become one of the most important food sources across the entire co...
A cryptic role for reciprocal helping in a cooperatively breeding bird
Abstract Identifying the mechanisms that underlie cooperation is fundamental to biology1. The most complex form of cooperation in vertebrates occurs in cooperative breeders, in which helpers...
Light-microscopy-based connectomic reconstruction of mammalian brain tissue
Abstract The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and fun...
Global dominance of seasonality in shaping lake-surface-extent dynamics
Brain tissue artificially expanded to show how neurons wire together
Activation of lysosomal iron triggers ferroptosis in cancer
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation
Abstract Impaired differentiation is a hallmark of myeloid malignancies1,2. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and ar...