Nature
Articles in this Issue
LRP8 is a receptor for tick-borne encephalitis virus
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies
Abstract Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in treating blood cancers, but CAR T cell dysfunction remains a common cause...
Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Modern sea-level rise breaks 4,000-year stability in southeastern China
Abstract Quantifying physical mechanisms driving sea-level change—including global mean sea level (GMSL) and regional-to-local components (that is, sea-level bud...
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Gigantic black holes did not have starring role in early cosmic transition
Dynamic fibroblast–immune interactions shape recovery after brain injury
Abstract Fibroblasts and immune cells coordinate tissue regeneration and necessary scarring after injury. In the brain, fibroblasts are border-enriched cells who...
DNA2 enables growth by restricting recombination-restarted replication
Abstract Nuclease–helicase DNA2 is a multifunctional genome caretaker that is essential for cell proliferation in a range of organisms, from yeast to human...