Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22

Elisia Villemure; Tom Januario; Mingshuo Zeng; Hanna G. Budayeva; Benjamin T. Walters; Aaron Lictao; Ke Sherry Li; Xiaofen Ye; Caroline L. Gilchrist; Bridget Hoag; Nicholas F. Endres; Peter L. Hsu; John Chan; Tommy K. Cheung; Michael R. Costa; Jean-Philippe Fortin; Noriko Ishisoko; Brett M. Babin; Joyce Liu; Alexandra Frommlet; Joachim Rudolph; Robert L. Yauch

doi:10.1038/s41467-025-64669-4

Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22

E Elisia Villemure T Tom Januario M Mingshuo Zeng H Hanna G. Budayeva B Benjamin T. Walters A Aaron Lictao K Ke Sherry Li X Xiaofen Ye C Caroline L. Gilchrist B Bridget Hoag N Nicholas F. Endres P Peter L. Hsu J John Chan T Tommy K. Cheung M Michael R. Costa J Jean-Philippe Fortin N Noriko Ishisoko B Brett M. Babin J Joyce Liu A Alexandra Frommlet J Joachim Rudolph R Robert L. Yauch

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published November 03, 2025

DOI 10.1038/s41467-025-64669-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (22)

E

Elisia Villemure

T

Tom Januario

M

Mingshuo Zeng

H

Hanna G. Budayeva

B

Benjamin T. Walters

A

Aaron Lictao

K

Ke Sherry Li

X

Xiaofen Ye

C

Caroline L. Gilchrist

B

Bridget Hoag

N

Nicholas F. Endres

P

Peter L. Hsu

J

John Chan

T

Tommy K. Cheung

M

Michael R. Costa

J

Jean-Philippe Fortin

N

Noriko Ishisoko

B

Brett M. Babin

J

Joyce Liu

A

Alexandra Frommlet

J

Joachim Rudolph

R

Robert L. Yauch

Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22

Article Details

Journal Info

Authors (22)

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