Nature Communications
Articles in this Issue
Speciation across depth gradients in reef corals
Improved analysis of in vivo drug combination experiments with a comprehensive statistical framework and web-tool
Deep-sea viral diversity and their role in host metabolism of complex organic matter
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Abstract Cereblon (CRBN) is an E3 ubiquitin ligase widely harnessed for targeted protein degradation (TPD). We report the discovery of a molecular glue degrader (MGD), MRT-31619, tha...
Star-branched polymer donors enabling high-performance organic solar cells with superior flexibility and intrinsic stretchability
Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis
Consistent response of European summers to the latitudinal temperature gradient over the Holocene
Abstract The drivers behind the current decadal trend toward longer and more extreme European summers are widely discussed. This is attributed to changes in the mid-latitude summer a...
Transformation-mediated and relaxation-assisted macroscopic tensile plasticity with strain-hardening in metallic glass
A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling
Octave-spanning supercontinuum generation from sub-millimeter-length integrated gallium phosphide waveguides
Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses
High-accuracy protein complex structure modeling based on sequence-derived structure complementarity
PRDX1 promotes testosterone synthesis and attenuates aging via redox regulation of ATG4B to modulate lipophagy
Controlling interfacial protein adsorption, desorption and aggregation in biomolecular condensates
Droplet surface spontaneous oxidation as a dominant formation pathway of organosulfates in the marine atmosphere
Position-specific ORF nucleoside-ribose modifications enabled by complete chemical synthesis enhance mRNA stability and translation
Advancing interdisciplinary science of gender is key to the success of blue carbon initiatives
Non-visual photoreceptive brain specification in sea urchin larvae
Abstract Centralized nervous systems enable animals to detect environmental cues and coordinate behavior, but their evolutionary origins in deuterostomes remain...
Reconstruction of the lymphatic system by transplantation of a centrifuge-based bioengineered lymphatic tissue
Abstract The increase in cancer incidence has accelerated the need for secondary lymphedema treatments after lymphadenectomy (LD) because lymph nodes cannot be regenerated. We demons...
A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation
Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resolution
Violence, city size and geographical isolation in African cities
Abstract Different types of violence are commonly linked with large urban areas, often presumed to scale superlinearly with population size (i.e., to be disproportionately higher in...
Amphipathic fluoroamine-functionalized hydrogels for enhanced selective removal of anionic pfas from water
Clinical and genomic features of Lynch syndrome differ by tumor site and disease spectrum
Abstract Lynch Syndrome (LS) carriers occasionally develop central nervous system (CNS) malignancies or tumors in organs not traditionally linked to the syndrome. These tumors are po...
Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy
Abstract Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty....