Position-specific ORF nucleoside-ribose modifications enabled by complete chemical synthesis enhance mRNA stability and translation

Hiroto Iwai; Yasuaki Kimura; Masakazu Honma; Kosuke Nakamoto; Atsushi Hashimoto; Keiichi Motosawa; Takayuki Atago; Kana Asano; Fumitaka Hashiya; Naoko Abe; Keiko Kobayashi; Ryoko Ogisu; Hiroki Yamada; Keiko Hiraishi; Seiji Saito; Junichiro Yamamoto; Hiroshi Abe

doi:10.1038/s41467-025-65788-8

Position-specific ORF nucleoside-ribose modifications enabled by complete chemical synthesis enhance mRNA stability and translation

H Hiroto Iwai Y Yasuaki Kimura M Masakazu Honma K Kosuke Nakamoto A Atsushi Hashimoto K Keiichi Motosawa T Takayuki Atago K Kana Asano F Fumitaka Hashiya N Naoko Abe K Keiko Kobayashi R Ryoko Ogisu H Hiroki Yamada (Japan Synchrotron Radiation Research Institute/SPring-8, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan) K Keiko Hiraishi S Seiji Saito J Junichiro Yamamoto H Hiroshi Abe

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published November 19, 2025

DOI 10.1038/s41467-025-65788-8

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (17)

H

Hiroto Iwai

Y

Yasuaki Kimura

M

Masakazu Honma

K

Kosuke Nakamoto

A

Atsushi Hashimoto

K

Keiichi Motosawa

T

Takayuki Atago

K

Kana Asano

F

Fumitaka Hashiya

N

Naoko Abe

K

Keiko Kobayashi

R

Ryoko Ogisu

H

Hiroki Yamada

Japan Synchrotron Radiation Research Institute/SPring-8, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan

K

Keiko Hiraishi

S

Seiji Saito

J

Junichiro Yamamoto

H

Hiroshi Abe

Position-specific ORF nucleoside-ribose modifications enabled by complete chemical synthesis enhance mRNA stability and translation

Article Details

Journal Info

Authors (17)

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