Nature Communications
Articles in this Issue
Small variant benchmark from a complete assembly of X and Y chromosomes
Abstract The sex chromosomes contain complex, important genes impacting medical phenotypes, but differ from the autosomes in their ploidy and large repetitive regions. To enable tech...
Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions
Abstract Protein lactylation is an emerging field. To advance the exploration of its biological functions, here we develop a comprehensive workflow that integrates proteomics to iden...
Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition
Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease
A tellurium iodide perovskite structure enabling eleven-electron transfer in zinc ion batteries
Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone promote antiviral immune response by activating NF-ĸB
Disruption of seasonal influenza circulation and evolution during the 2009 H1N1 and COVID-19 pandemics in Southeastern Asia
MPicker: visualizing and picking membrane proteins for cryo-electron tomography
Abstract Advancements in cryo-electron tomography (cryoET) allow the structure of macromolecules to be determined in situ, which is crucial for studying membrane protein structures a...
A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD
Abstract An abnormal expansion of a GGGGCC (G 4 C 2 ) hexanucleotide repeat in th...
CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses
Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy
Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae
Abstract The replication of the two chromosomes in the pathogenic bacterium Vibrio cholerae is coordinated by the binding...
Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity
MoS2-confined Rh-Zn atomic pair boosts photo-driven methane carbonylation to acetic acid
Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules
Electrostatic in-plane structural superlubric actuator
Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals
AbstractThe analysis of circulating tumour DNA (ctDNA) through minimally invasive liquid biopsies is promising for early multi-cancer detection and monitoring minimal residual disease. Most existing m...
Unveiling the nexus between irradiation and phase reconstruction in tin-lead perovskite solar cells
AbstractTin-lead perovskites provide an ideal bandgap for narrow-bandgap perovskites in all-perovskite tandem solar cells, fundamentally improving power conversion efficiency. However, light-induced d...
Ultra-light antennas via charge programmed deposition additive manufacturing
AbstractThe demand for lightweight antennas in 5 G/6 G communication, wearables, and aerospace applications is rapidly growing. However, standard manufacturing techniques are limited in structural com...
Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK
AbstractUncertainty remains regarding the role of diet in colorectal cancer development. We examined associations of 97 dietary factors with colorectal cancer risk in 542,778 Million Women Study parti...
AFM observation of protein translocation mediated by one unit of SecYEG-SecA complex
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism
Enhancing photocatalytic hydrogen peroxide generation by tuning hydrazone linkage density in covalent organic frameworks
Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2
Abstract Multidrug resistance-associated protein 2 (MRP2) is an ATP-powered exporter important for maintaining liver homeostasis and a potential contributor to chemotherapeutic resis...