Nature Communications
Articles in this Issue
Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial
AbstractCombined immune checkpoint blockade (ICB) and chemoradiation (CRT) is approved in patients with locally advanced cervical cancer (LACC) but optimal sequencing of CRT and ICB is unknown. NRG-GY...
Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner
AbstractCompetition among bacteria for carbohydrates is pivotal for colonization resistance (CR). However, the impact of Western-style diets on CR remains unclear. Here we show how the competition bet...
Oscillatory mechanoluminescence of Mn2+-doped SrZnOS in dynamic response to rapid compression
Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection
Abstract Influenza remains a persistent global health challenge, largely due to the virus’ continuous antigenic drift and occasional shift, which impede the development of a universa...
Photocatalytic asymmetric C-C coupling for CO2 reduction on dynamically reconstructed Ruδ+-O/Ru0-O sites
Hyperedge overlap drives explosive transitions in systems with higher-order interactions
Author Correction: Native RNA nanopore sequencing reveals antibiotic-induced loss of rRNA modifications in the A- and P-sites
Distinct patterns of volcano deformation for hot and cold magmatic systems
AbstractVolcano deformation can be detected over timescales from seconds to decades, offering valuable insights for magma dynamics. However, these signals are shaped by the long-term evolution of magm...
Wireless microwave-to-optical conversion via programmable metasurface without DC supply
Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension
Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8
Abstract After a peripheral nerve injury, Schwann cells (SCs), the myelinating glia of the peripheral nervous system, convert into repair cells that foster axonal regrowth, and then...
The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization
Abstract Although sex determination is a fundamental process in vertebrate development, it is very plastic. Diverse genes became major sex determinants in teleos...
Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
AbstractIt remains unclear whether the benefits of adhering to a healthy lifestyle outweigh the effects of high genetic risk on cognitive decline. We examined the association of combined lifestyle fac...
Systematically developing a registry of splice-site creating variants utilizing massive publicly available transcriptome sequence data
Abstract Genomic variants causing abnormal splicing play important roles in genetic disorders and cancer development. Among them, variants that cause the formati...
High-impedance microwave resonators with two-photon nonlinear effects
AbstractNonlinear effects play a central role in photonics as they form the foundation for most of the device functionalities such as amplification and quantum state preparation and detection. Typical...
Impact of population screening for Lynch syndrome insights from the All of Us data
Author Correction: Pervasive fire danger continued under a negative emission scenario
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation
AbstractMutations in RAS and PI3Kα are major drivers of human cancer. Their interaction plays a crucial role in activating PI3Kα and amplifying the PI3K-AKT-mTOR pathway. Disrupting RAS-PI3Kα interact...
Coverage bias in small molecule machine learning
Abstract Small molecule machine learning aims to predict chemical, biochemical, or biological properties from molecular structures, with applications such as toxicity prediction, lig...
Vertex model with internal dissipation enables sustained flows
AbstractComplex tissue flows in epithelia are driven by intra- and inter-cellular processes that generate, maintain, and coordinate mechanical forces. There has been growing evidence that cell shape a...