Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

Max Cigrang; Julian Obid; Maguelone Nogaret; Léane Seno; Tao Ye; Guillaume Davidson; Philippe Catez; Pietro Berico; Clara Capelli; Clara Marechal; Amélie Zachayus; Clémence Elly; Marie Jose Guillen Navarro; Marta Martinez Diez; Gema Santamaria Nunez; Tsai-Kun Li; Emmanuel Compe; Pablo Aviles; Irwin Davidson; Jean-Marc Egly; Carmen Cuevas; Frédéric Coin

doi:10.1038/s41467-024-55667-z

Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

M Max Cigrang J Julian Obid M Maguelone Nogaret L Léane Seno T Tao Ye (State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China) G Guillaume Davidson P Philippe Catez P Pietro Berico C Clara Capelli C Clara Marechal A Amélie Zachayus C Clémence Elly M Marie Jose Guillen Navarro M Marta Martinez Diez G Gema Santamaria Nunez T Tsai-Kun Li E Emmanuel Compe P Pablo Aviles I Irwin Davidson J Jean-Marc Egly C Carmen Cuevas F Frédéric Coin

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published January 08, 2025

DOI 10.1038/s41467-024-55667-z

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (22)

M

Max Cigrang

J

Julian Obid

M

Maguelone Nogaret

L

Léane Seno

T

Tao Ye

State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China

G

Guillaume Davidson

P

Philippe Catez

P

Pietro Berico

C

Clara Capelli

C

Clara Marechal

A

Amélie Zachayus

C

Clémence Elly

M

Marie Jose Guillen Navarro

M

Marta Martinez Diez

G

Gema Santamaria Nunez

T

Tsai-Kun Li

E

Emmanuel Compe

P

Pablo Aviles

I

Irwin Davidson

J

Jean-Marc Egly

C

Carmen Cuevas

F

Frédéric Coin

Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

Article Details

Journal Info

Authors (22)

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