Nature Communications
Articles in this Issue
DrBioRight 2.0: an LLM-powered bioinformatics chatbot for large-scale cancer functional proteomics analysis
Addressable and perceptible dynamic reprogram of ferromagnetic soft machines
Deep learning-driven pulmonary artery and vein segmentation reveals demography-associated vasculature anatomical differences
Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations
Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups
Abstract Uterine leiomyomata or fibroids are highly heritable, common, and benign tumors of the uterus with poorly understood etiology. Previous GWAS have reported 72 associated genes but in...
SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection
Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects
Abstract Virtual library docking can reveal unexpected chemotypes that complement the structures of biological targets. Seeking agonists for the cannabinoid-1 receptor (CB1R), we dock 74 mil...
Surface hydrogen migration significantly promotes electroreduction of acetonitrile to ethylamine
A fast approach for structural and evolutionary analysis based on energetic profile protein comparison
Abstract In structural bioinformatics, the efficiency of predicting protein similarity, function, and evolutionary relationships is crucial. Our approach proposed herein leverages pr...
Knowledge-guided diffusion model for 3D ligand-pharmacophore mapping
Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib
Quantifying the distinct role of plasmon enhancement mechanisms in prototypical antenna-reactor photocatalysts
Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species
Abstract Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitoc...
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation
Abstract The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the...
Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection
Endogenous opioid receptors and the feast or famine of maladaptive feeding
Artificial intelligence for breast cancer screening in mammography (AI-STREAM): preliminary analysis of a prospective multicenter cohort study
Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility
Abstract The co-occurrence of autism and gastrointestinal distress is well-established, yet the molecular underpinnings remain unknown. The identification of hig...
Structural basis of Nipah virus RNA synthesis
Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to...