Nature Communications
Articles in this Issue
Drosophila ovarian stem cell niche ageing involves coordinated changes in transcription and alternative splicing
Abstract Gene expression (GE) and alternative splicing (AS) contribute to the formation of new interaction networks with potentially significant cellular functions. Here, we investigate agei...
Discovering organic reactions with a machine-learning-powered deciphering of tera-scale mass spectrometry data
Neural signatures of temporal anticipation in human cortex represent event probability density
Abstract Temporal prediction is a fundamental function of neural systems. Recent results show that humans anticipate future events by calculating probability density functions, rathe...
Prioritizing involuntary immobility in climate policy and disaster planning
Abstract Globally, populations are increasingly located in areas at high risk of climate change impacts. Some populations lack the agency to move out of harm’s way, leading to involuntary im...
Enhanced RNA-targeting CRISPR-Cas technology in zebrafish
Axonal RNA localization is essential for long-term memory
Abstract Localization of mRNAs to neuronal terminals, coupled to local translation, has emerged as a prevalent mechanism controlling the synaptic proteome. However, the physiological regulat...
Neurotransmitters’ white matter mapping unveils the neurochemical fingerprints of stroke
Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex
Abstract Acetyl-CoA synthetase (Acs) generates acetyl-coenzyme A (Ac-CoA) but its excessive activity can deplete ATP and lead to a growth arrest. To prevent this, Acs is regulated through Ac...
Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner
Abstract Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus...
Uncovering local integrability in quantum many-body dynamics
A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat
Spatiotemporally resolved mapping of extracellular proteomes via in vivo-compatible TyroID
Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling
Abstract Fetal cell ablation models are crucial for studying congenital diseases, organ regeneration, and xenotransplantation. However, conventional knockout models offer limited control ove...
Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model
Early warning of complex climate risk with integrated artificial intelligence
Abstract As climate change accelerates, human societies face growing exposure to disasters and stress, highlighting the urgent need for effective early warning systems (EWS). These systems m...
Phototropin connects blue light perception to starch metabolism in green algae
Abstract In photosynthetic organisms, light acts as an environmental signal to control their development and physiology, as well as energy source to drive the co...
High-dose vitamin D3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM)
Abstract We have previously shown that high-dose vitamin D3 improved weight gain and neurodevelopmental indices in children receiving standard therapy for uncomplicated severe acute malnutri...
Asymmetric reductive arylation and alkenylation to access S-chirogenic sulfinamides
Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes
DTIAM: a unified framework for predicting drug-target interactions, binding affinities and drug mechanisms
Site-specific synergy in heterogeneous single atoms for efficient oxygen evolution
Abstract Heterogeneous single-atom systems demonstrate potential to break performance limitations of single-atom catalysts through synergy interactions. The synergy in heterogeneous single a...
Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug
Abstract Motor disability is a critical impairment in stroke patients. Rehabilitation has a limited effect on recovery; but there is no medical therapy for post-stroke recovery. The biologic...
Light-driven plasmonic microrobot for nanoparticle manipulation
Abstract Recently light-driven microdrones have been demonstrated, making use of plasmonic nanomotors based on directional resonant chiral light scattering. These nanomotors can be addressed...