Nature Communications
Articles in this Issue
Cortico-striatal circuit mechanisms drive the effects of D1 dopamine agonists on memory capacity in mice through cAMP/PKA signalling
Giant self spin-valve effect in the kagome helimagnet
CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis
Climate warming may undermine sleep duration and quality in repeated-measure study of 23 million records
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Abstract Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent...
Transcriptional heterogeneity shapes stress-adaptive responses in yeast
Abstract In response to stress, cells activate signaling pathways that coordinate broad changes in gene expression to enhance cell survival. Remarkably, complex variations in gene expression...
A 700-year rupture sequence of great eastern Aleutian earthquakes from tsunami modeling of stratigraphic records
Semi-automated IT-scATAC-seq profiles cell-specific chromatin accessibility in differentiation and peripheral blood populations
Abstract Single-cell ATAC-seq (scATAC-seq) enables high-resolution mapping of chromatin accessibility but is often limited by throughput, cost, and equipment requirements. Here, we present i...
Habitat openness and squamate color evolution over deep time
Abstract While the ecological roles of colored integument have been extensively studied, what regulates global patterns of color variation remains poorly understood. Here, using a global dat...
Entropy scaling for diffusion coefficients in fluid mixtures
Abstract Entropy scaling is a powerful technique that has been used for predicting transport properties of pure components over a wide range of states. However, modeling mixture diffusion co...
Three-quarters of species’ ranges have not been covered by protected areas in global borders
Bacterial Hachiman complex executes DNA cleavage for antiphage defense
Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β
Abstract Single-strand breaks (SSBs) are one of the most prevalent forms of DNA damage found in the chromatinized genome and are repaired by single-strand break repair (SSBR) or base...
Monitoring, modeling, and forecasting long-term changes in coastal seawater quality due to climate change
Histopathology based AI model predicts anti-angiogenic therapy response in renal cancer clinical trial
Abstract Anti-angiogenic (AA) therapy is a cornerstone of metastatic clear cell renal cell carcinoma (ccRCC) treatment, but not everyone responds, and predictive biomarkers are lacking. CD31...
Miniature origami robot for various biological micromanipulations
Genetically encoding ε-N-methacryllysine into proteins in live cells
IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia
Abstract Invasive C. albicans infections result in high mortality rates. While IL-1 is important to combat C. albicans infections, the underlying mechanisms remain unclear. Using global and...
Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles
Abstract Hereditary SDHB -mutant pheochromocytomas (PC) and paragangliomas (PG) are rare tumours with a high propensity t...
Observation of the spiral spin liquid in a triangular-lattice material
Abstract The spiral spin liquid (SSL) is a highly degenerate state characterized by a continuous contour or surface in reciprocal space spanned by a spiral propagation vector. Although the S...