Nature Communications
Articles in this Issue
Contributions of biological and physical dynamics to deglacial CO2 release from the polar Southern Ocean
Unraveling the neurophysiological correlates of phase-specific enhancement of motor memory consolidation via slow-wave closed-loop targeted memory reactivation
Abstract Memory consolidation can be enhanced during sleep using targeted memory reactivation (TMR) and closed-loop (CL) acoustic stimulation on the up-phase of slow oscillations (SOs). Here...
Giant Rashba splitting in PtTe/PtTe2 heterostructure
Abstract Achieving a large spin splitting is highly desirable for spintronic devices, which often requires breaking of the inversion symmetry. However, many atomically thin films are centros...
Complement-mediated enhancement of SARS-CoV-2 antibody neutralisation potency in vaccinated individuals
Abstract With the continued emergence of SARS-CoV-2 variants and concerns of waning immunity, there is a need for better defined correlates of protection to aid future vaccine and th...
An epidermal serine sensing system for skin healthcare
Diverse ancestral representation improves genetic intolerance metrics
Abstract The unprecedented scale of genomic databases has revolutionized our ability to identify regions in the human genome intolerant to variation—regions ofte...
Real-world evidence provides clinical insights into tissue-agnostic therapeutic approvals
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations
Abstract Heterogeneity is inherent to living organisms and it determines cell fate and phenotypic variability. Despite its ubiquity, the underlying molecular mechanisms and the genet...
Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition
Abstract Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However,...
Probable evidence for a transient mega-electron volt emission line in the GRB 221023A
Genomic structural variation in an alpha/beta hydrolase triggers hybrid necrosis in wheat
Ceramic-carbon Janus membrane for robust solar-thermal desalination
Abstract The desalination performance of conventional distillation membranes is limited by insufficient stability and energy efficiency, impeding their application in sustainable water produ...
A phenopushing platform to identify compounds that alleviate acute hypoxic stress by fast-tracking cellular adaptation
Abstract Severe acute hypoxic stress is a major contributor to the pathology of human diseases, including ischemic disorders. Current treatments focus on managing consequences of hypoxia, wi...
Rational design of optimal bimetallic and trimetallic nickel-based single-atom alloys for bio-oil upgrading to hydrogen
Parity-dependent state transfer for direct entanglement generation
Abstract As quantum information technologies advance, challenges in scaling and connectivity persist, particularly the need for long-range qubit connectivity and efficient entanglement gener...
8-bit states in 2D floating-gate memories using gate-injection mode for large-scale convolutional neural networks
Marine biogenic humic substances control iron biogeochemistry across the Southern Ocean
Abstract Iron, which is an essential element for marine photosynthesis, is sparingly soluble in seawater. In consequence, iron bioavailability controls primary productivity in up to 40% of t...
Ultrahigh dielectric permittivity in Hf0.5Zr0.5O2 thin-film capacitors
Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with Ninetails
Abstract Stability and translation of mRNAs, both endogenous and therapeutic, is determined by poly(A) tail. Direct RNA sequencing enables single-molecule measurements of poly(A) lengths, av...
Carbene-activated stannylenes to access selective C(sp3)–H bond scission at the steric limit
Abstract The ubiquity of N-heterocyclic carbenes (NHCs) in diverse areas of chemical research typically arises from their potent stabilising capabilities and role as innocent spectators to s...
HSD17B4 deficiency causes dysregulation of primary cilia and is alleviated by acetyl-CoA
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood
Abstract Childhood emotional and behavioural difficulties tend to co-occur and often precede diagnosed neuropsychiatric conditions. Identifying shared and specific risk factors for e...
Metabolomics strategy for diagnosing urinary tract infections
Global gridded population datasets systematically underrepresent rural population
Abstract Numerous initiatives towards sustainable development rely on global gridded population data. Such data have been calibrated primarily for urban environments, but their accuracy in t...