Nature Communications
Articles in this Issue
Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain
Abstract The 70 kDa heat shock protein (Hsp70) family of molecular chaperones ensures protein biogenesis and homeostasis, driven by ATP hydrolysis. Here, we intr...
Single-chip silicon photonic engine for analog optical and microwave signals processing
Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice
The bandgap-detuned excitation regime in photonic-crystal resonators
Abstract Control of nonlinear interactions in microresonators enhances access to classical and quantum field states across nearly limitless bandwidth. A recent innovation has been to...
Precision multiplexed base editing in human cells using Cas12a-derived base editors
Abstract Base editors enable the direct conversion of target nucleotides without introducing DNA double strand breaks, making them a powerful tool for creating point mutations in a human gen...
Cell division protein CdpA organises and anchors the midcell ring in haloarchaea
Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians
The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells
Abstract Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here,...
Triple energy conversion cascade in a densely charged redox active covalent organic actuator
Allosteric amyloid catalysis by coiled coil fibrils
Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics
Preserving fruit freshness with amyloid-like protein coatings
Soil microbial responses to multiple global change factors as assessed by metagenomics
Abstract Anthropogenic activities impose multiple concurrent pressures on soils globally, but responses of soil microbes to multiple global change factors are poorly understood. Here...
Refresh organic electrodes for high-power and long-cycle applications
Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment
varVAMP: degenerate primer design for tiled full genome sequencing and qPCR
Abstract Time- and cost-saving surveillance of viral pathogens is achieved by tiled sequencing in which a viral genome is amplified in overlapping PCR amplicons and qPCR. However, designing...
Anlotinib plus toripalimab as a first-line treatment in patients with advanced gastric cancer and performance status 2: the phase II APICAL-GC trial
Endolysosomal processing of neuron-derived signaling lipids regulates autophagy and lipid droplet degradation in astrocytes
Ultralow-threshold upconversion infrared vision via a microsphere-mediated directional photofield
Circular RNA-mediated inverse prime editing in human cells
Timing the escape of a photoexcited electron from a molecular cage
Abstract Charge transfer is fundamentally dependent on the overlap of the orbitals comprising the transport pathway. This has key implications for molecular, nanoscale, and quantum technolog...
Interspecies hydrogen transfer between cyanobacteria and symbiotic bacteria drives nitrogen loss
Wetland fragmentation associated with large populations across Africa
Abstract Wetlands provide essential ecosystem services in Africa, yet their extent and fragmentation remain poorly understood. Here we classify African wetlands at 10 m resolution, using sea...
Eomesodermin in conjunction with the BAF complex promotes expansion and invasion of the trophectoderm lineage
Abstract The T-box transcription factor (TF) Eomesodermin/Tbr2 (Eomes) is essential for maintenance of the trophectoderm (TE) lineage, but the molecular mechanisms underlying this critical r...
Photochemical synthesis of natural lipids in artificial and living cells
Abstract Lipid synthesis plays a central role in cell structure, signaling, and metabolism. A general method for the abiogenesis of natural lipids could transform the development of lifelike...