Nature Communications
Articles in this Issue
Topochemical synthesis of chiroptical materials through charge-transfer/Diels–Alder cascade reaction
In-silico 3D molecular editing through physics-informed and preference-aligned generative foundation models
Chemotactic navigation in robotic swimmers via reset-free hierarchical reinforcement learning
Tracking international and regional dissemination of the KPC/NDM co-producing Klebsiella pneumoniae
Nanonet trapping for effective removal of nanoplastics by iron coagulation
Thalamocortical feedback selectively controls pyramidal neuron excitability
Abstract The apical dendrites of layer (L) 2/3 pyramidal neurons in the mouse somatosensory cortex integrate synaptic input from long-range projections. Among those, inputs from the higher-o...
Structural insights into the human HRD1 ubiquitin ligase complex
Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolution
Inorganic-bacterial biohybrids for efficient solar-driven nitrogen fixation
Evaluating cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles
In situ cryo-electron tomography reveals the progressive biogenesis of basal bodies and cilia in mouse ependymal cells
Abstract Cilia, essential organelles for cell motility and signaling, comprise an axoneme extended from the basal body (BB). The assembly process of BBs and axonemes during ciliogenesis, how...
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
LLM-generated messages can persuade humans on policy issues
Abstract The emergence of large language models (LLMs) has made it possible for generative artificial intelligence (AI) to tackle many higher-order cognitive tas...
A machine learning model using clinical notes to identify physician fatigue
Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing
LassoPred: a tool to predict the 3D structure of lasso peptides
The urgent electrolyte sustainability challenges for electric vehicle batteries
GPerturb: Gaussian process modelling of single-cell perturbation data
Abstract Single-cell RNA sequencing and CRISPR screening enable high-throughput analysis of genetic perturbations at single-cell resolution. Understanding combinatorial perturbation...
The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial
Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells
Abstract In eukaryotic cells, reactive oxygen species (ROS) serve as crucial signaling components. ROS are potentially toxic, so constant adjustments are needed to maintain cellular health....
A genotype-to-drug diffusion model for generation of tailored anti-cancer small molecules
A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma
CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage
Abstract The SLFN14 endoribonuclease is a post-transcriptional regulator that targets the ribosome and its associated RNA substrates for codon-bias translational repression. SLFN14 nuclease...
Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa
Abstract Although viral suppression is attained for most adults living with diagnosed HIV in East, Central, Southern and West Africa (ECSWA), challenges remain with sustained adheren...
The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress
Abstract RIF1 is a multifunctional protein that regulates DNA replication and repair. RIF1-deficient cells are hypersensitive to DNA replication stress. Of the two alternatively spli...