Nature Communications
Articles in this Issue
Decoding polyubiquitin regulation of KV7. 1 (KCNQ1) surface expression with engineered linkage-selective deubiquitinases
Abstract Polyubiquitin chain diversity generates a ‘ubiquitin code’ that universally regulates protein abundance, localization, and function. Functions of polyubiquitin diversity are mostly...
Flavoproteins as native and genetically encoded spin probes for in cell ESR spectroscopy
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression
Prevalent chromosome fusion in Vibrio cholerae O1
Abstract Two circular chromosomes are a defining feature of the bacterial family Vibrionaceae, including the pathogen Vibrio cholerae, with rare reports of isolates with a single, fused chro...
Charting γ-secretase substrates by explainable AI
Abstract Proteases recognize substrates by decoding sequence information—an essential cellular process elusive when recognition motifs are absent. Here, we unravel this problem for γ-secreta...
In-material physical computing based on reconfigurable microwire arrays via halide-ion segregation
Facilitate integrated analysis of single cell multiomic data by binarizing gene expression values
Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy
Experimental demonstration of third-order memristor-based artificial sensory nervous system for neuro-inspired robotics
Abstract The sensory nervous system in animals enables the perception of external stimuli. Developing an artificial sensory nervous system has been widely conducted to realize neuro-inspired...
An mRNA vaccine encoding five conserved Group A Streptococcus antigens
Tailored amination enables switchable synthesis of α- and γ-amino acid derivatives from extended quinone methides
Engineered Sdd7 cytosine base editors with enhanced specificity
Nuclear quantum effects in molecular liquids across chemical space
Abstract Nuclear quantum effects (NQEs) influence many physical and chemical phenomena, particularly those involving light atoms or occurring at low temperatures. However, their impact has b...
Multi-representation domain attentive contrastive learning based unsupervised automatic modulation recognition
The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis
The iron chelator pulcherriminic acid mediates the light response in Bacillus subtilis biofilms
Nonlinear Chiral-like State Transfer realized with a minimal set of parameters
Abstract Chiral state transfers (CSTs) associated with exceptional points are always under the scrutiny of theoretical and experimental science, owing to its exotic physics and fascinating p...
Benchmark dataset and deep learning method for global tropical cyclone forecasting
Abstract Accurate tropical cyclone (TC) forecasting is critical for disaster prevention. While deep learning shows promise in weather prediction, existing approaches demonstrate limited accu...