Nature Communications

RNA triphosphatase-mediated mRNA capping is essential for maintaining transcript homeostasis and the survival of Toxoplasma gondii

Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies

MassCube improves accuracy for metabolomics data processing from raw files to phenotype classifiers

Abstract Nontargeted peak detection in LC-MS-based metabolomics must become robust and benchmarked. We present MassCube, a Python-based open-source framework for...

Risks of relying on uncertain carbon dioxide removal in climate policy

Mapping the regulatory genetic landscape of complex traits using a chicken advanced intercross line

Phage-mediated peripheral kill-the-winner facilitates the maintenance of costly antibiotic resistance

Abstract The persistence of antibiotic resistant (AR) bacteria in the absence of antibiotic pressure raises a paradox regarding the fitness costs associated with...

ToxACoL: an endpoint-aware and task-focused compound representation learning paradigm for acute toxicity assessment

An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling

Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Flow-induced 2D nanomaterials intercalated aligned bacterial cellulose

Brain region-specific gain modulation of place cells by VIP neurons

A ferritin-targeted biohybrid triggering ferroptosis immunotherapy via activating endogenous iron and replenishing exogenous iron simultaneously

Machine Learning simulations reveal oxygen’s phase diagram and thermal properties at conditions relevant to white dwarfs

Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial

A rationally thin composite membrane with differentiated pore structure for industrial-scale alkaline water electrolysis

Isotopologue-induced structural dynamics of a triazolate metal-organic framework for efficient hydrogen isotope separation

Abstract Efficient hydrogen isotope separation remains the biggest challenge due to the nearly identical physicochemical properties of H2 and D2. Through in situ neutron powder diffraction a...

The clinical effectiveness of sodium-glucose co-transporter-2 inhibitors on prognosis of patients with chronic obstructive pulmonary disease and diabetes

Microenvironment-feedback regulated hydrogels as living wound healing materials

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues

Longitudinal changes in brain asymmetry track lifestyle and disease

Structural and functional insights of AmpG in muropeptide transport and multiple β-lactam antibiotics resistance

Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice

Abstract Microglia and border associated macrophages have been implicated in hypercapnia, but it is unknown which myeloid cell modulates which vessel type. Previously, we documented...

Highly ordered clustering of TNFα and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

Abstract In eukaryotic cells, splicing occurs predominantly co-transcriptionally, enhancing splicing efficiency and fidelity while introducing an additional layer of regulation over...

Evolution of linear triterpenoid biosynthesis within the Euphorbia genus

Abstract Terpenoids are among the largest classes of plant natural products. Squalene, a high value commodity in the cosmetic, food and pharmaceutical industries, is a common linear precurso...