Nature Communications
Articles in this Issue
A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization
METTL9 sustains vertebrate neural development primarily via non-catalytic functions
Abstract METTL9 is an enzyme catalysing N1-methylation of histidine residues (1MH) within eukaryotic proteins. Given its high expression in vertebrate nervous system and its potential associ...
Nanoscale cuticle mass density variations influenced by pigmentation in butterfly wing scales
March5-mediated Trim28 degradation preserves islet β-cell function in mice
Cryo-EM captures early intermediate steps in dynein activation by LIS1
Abstract Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes...
Mechanical–electric dual characteristics solid–liquid interfacing sensor for accurate liquid identification
Kerr non-linearity enhances the response of a graphene Josephson bolometer
Disentangling extracellular current of electroactive bacteria with oblique-incidence reflection difference imaging
Health risks and genetic architecture of objectively measured multidimensional sleep health
Fully exposed Ptn cluster catalysts enable cascade oxidation of polyol to dicarboxylic acid
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
Insights into a water-mediated catalytic triad architecture in CE20 carbohydrate esterases
Abstract Carbohydrate esterases modify polysaccharides by removing different ester moieties thereby affecting their physicochemical properties and their accessibility by glycoside hydrolases...
vPro-MS enables identification of human-pathogenic viruses from patient samples by untargeted proteomics
Abstract Viral infections are commonly diagnosed by the detection of viral genome fragments or proteins using targeted methods such as PCR and immunoassays. In contrast, metagenomics enables...
A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis
A transcription factor ensemble orchestrates bundle sheath expression in rice
Abstract C4 photosynthesis has evolved in over sixty plant lineages and improves photosynthetic efficiency by ~50%. One unifying character of C4 plants is photosynthetic activation of a comp...
A framework for complex signal processing via synthetic biological operational amplifiers
Local structural distortions drive magnetic molecular field in compositionally complex spinel oxide
Cholesterol modulates membrane elasticity via unified biophysical laws
mRNA trafficking directs cell-size-scaling of mitochondria distribution and function
Abstract The subcellular positioning of organelles is critical to their function and is dynamically adapted to changes in cell morphology. Yet, how cells sense s...
Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation
Non-equilibrium anti-Stokes Raman spectroscopy for investigating Higgs modes in superconductors
Abstract Even before its role in electroweak symmetry breaking, the Anderson-Higgs mechanism was introduced to explain the Meissner effect in superconductors. Spontaneous symmetry-breaking y...
A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
RSGPT: a generative transformer model for retrosynthesis planning pre-trained on ten billion datapoints
Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR
Abstract The M5 muscarinic acetylcholine receptor (M5 mAChR) represents a promising therapeutic target for neurological disorders. However, the high conservation of its orthosteric binding s...