Nature Communications
Articles in this Issue
Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination
Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger
Abstract Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute malnutrition (SAM) but this may exacerbate antimicrobial resistance. Here...
The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness
Abstract Extrachromosomal and mobile genetic elements, including plasmids, and accessory chromosomes, are prevalent in all life domains. Elements integrated into the host chromosome replicat...
Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs
Abstract The family of ρ-type GABAA receptors includes potential therapeutic targets in several neurological conditions, and features distinctive pharmacology compared to other subtypes. Her...
Multiple bursts of speciation in Madagascar’s endangered lemurs
Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism
Abstract Hyperactivation of the cystic fibrosis transmembrane conductance regulator (CFTR) contributes to secretory diarrhea, a major cause of pediatric mortality worldwide, and autosomal do...
Computational study of terahertz-driven controllable molecular isomerization
Dynamic birefringence and chirality of magnetically controllable assemblies of anisotropic plasmonic nanoparticles in dispersion
Abstract The ability to control the orientation and arrangement of plasmonic nanoparticles with shape anisotropy offers a promising route to achieving highly tunable optical properties. In t...
Development and application of GlycanDIA workflow for glycomic analysis
Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging
3D quantification of nanolites using X-ray ptychography reveals syn-eruptive nanocrystallisation impacts magma rheology
Abstract Nanoscale crystals are becoming increasingly recognised in the products of volcanic eruptions, spanning a range of magma compositions. The crystallisation of nanolites impacts magma...
PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility
Abstract In oocytes of mammals and other animals, gene regulation is mediated primarily through changes in poly(A)-tail length. Here, we introduce PAL-AI, an integrated neural network machin...
Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies
Abstract Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influ...
Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord
Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia
Coastal aquifers key contributors to ocean chemistry through solute fluxes
Brightening self-trapped exciton emission in 2D metal-organic chalcogenolates via argentophilicity-mediated anisotropic compression
Serological evidence of clade Ib Mpox transmission by sex workers and within household in South Kivu, DRC
Read my LIPSS: organic lasers on micromachined resonators
Abstract Thin-film lasers based on organic semiconductors offer significant potential for miniaturized sensing and optical memory. We present a new method for creating first-order distribute...
USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4
Abstract In mouse, minor zygotic genome activation (ZGA) precedes and is essential for major ZGA in two-cell (2C) embryos. A subset of ZGA genes (known as “2C” genes) are also activated in a...
Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells
Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia
Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial
A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate COVID-19
Abstract Effective and reliable treatments for SARS-CoV-2 infections are a key part of global COVID-19 management. Based on vitro studies, niclosamide has been considered as a potential drug...