Nature Communications
Articles in this Issue
An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution
Abstract Understanding the brain’s molecular diversity requires spatially resolved maps of transcripts and proteins across regions and compartments. Here, we per...
Multi-state catch bond formed in the Izumo1:Juno complex that initiates human fertilization
Abstract Izumo1:Juno-mediated adhesion between sperm and egg cells is essential for mammalian sexual reproduction. However, conventional biophysical and structural approaches have provided o...
Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle
Multiplex bead assays enable integrated serological surveillance and reveal cross-pathogen vulnerabilities in Zambezia Province, Mozambique
Abstract Multiplex serological assays simultaneously measure antibodies to multiple antigens, furnishing insights into exposure and susceptibility to several pathogens and cross-pathogen vul...
Trait anxiety is associated with reduced reward-related replay at rest
Subsecond optically controlled domain switching in freestanding ferroelectric BaTiO3 membrane
A salt-free medium facilitating electrode prelithiation towards fast-charging and high-energy lithium-ion batteries
Abstract The substantial consumption of lithium ions and sluggish reaction kinetics at the anode detrimentally impact the deliverable energy and fast-charging capability of lithium-ion batte...
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states
Abstract The Nucleocapsid protein (N) of SARS-CoV-2 plays a critical role in the viral lifecycle by regulating RNA replication and by packaging the viral genome. N and RNA phase sepa...
Bringing the uncultivated microbial majority of freshwater ecosystems into culture
Abstract Axenic cultures are essential for studying microbial ecology, evolution, and genomics. Despite the importance of pure cultures, public culture collections are biased towards...
Interferon-stimulated gene screening identifies CCND3 as a host restriction factor against emerging high-pathogenic bandaviruses
DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides
Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method
scIVNL-seq resolves in vivo single-cell RNA dynamics of immune cells during Salmonella infection
Defining the cell and molecular origins of the primate ovarian reserve
Abstract The primate ovarian reserve is established during late fetal development and consists of quiescent primordial follicles in the ovarian cortex each composed of granulosa cell...
Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer’s disease
Abstract A growing body of evidence shows that epileptic activity is frequently observed in patients with Alzheimer’s disease (AD), implicating underlying excitatory-inhibitory imbalance. Th...
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins
Abstract Programmable epigenome editors modify gene expression in mammalian cells by altering the local chromatin environment at target loci without inducing DNA breaks. However, the...
Strong crystalline thermal insulation induced by extended antibonding states
SeeThrough: a rationally designed skull clearing technique for in vivo brain imaging
Catalytic refining lignin into toluene over atomically dispersed Cu/Ni dual sites
Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions
Abstract The liver proteome undergoes dynamic changes while performing hundreds of essential biological functions. Dysregulation of the liver proteome under alcoholic conditions leads to alc...
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement
Abstract Lineage switching (LS) is the conversion of cancer cell lineage during the course of a disease. LS in leukemia cell lineage facilitates cancer cells escaping targeting strategy like...
Predictive design of crystallographic chiral separation
Abstract The efficient separation of chiral molecules is a fundamental challenge in the manufacture of pharmaceuticals and light-polarising materials. We developed an approach that combines...