Nature Communications
Articles in this Issue
High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models
Abstract Missense mutations in the 12th codon of KRAS are key drivers of lung cancer, with glycine-to-cysteine (G12C) and glycine-to-aspartic acid (G12D) substitutions being among the most p...
Transboundary conflict from surface water scarcity under climate change
Coordinated active repression operates via transcription factor cooperativity and multiple inactive promoter states in a developing organism
Abstract Refining transcriptional levels via active repression in a euchromatic context represents a critical regulatory process. While the molecular players of...
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
Abstract Inflammation is increasingly recognized as a risk factor for psychiatric disorders. Animal models of stress and stress-related disorders are associated with blood neutrophilia. The...
A quadratic paradigm describes the relationship between phenotype severity and variation
Low-temperature molten-salt enabled synthesis of highly-efficient solid-state emitting carbon dots optimized using machine learning
Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer’s disease mouse model
Abstract Understanding how amyloid beta (Aβ) plaques develop and lead to neurotoxicity in Alzheimer’s disease remains a major challenge, particularly given the t...
Single-molecule fluorescence microscopy reveals regulatory mechanisms of MYO7A-driven cargo transport in stereocilia of live inner ear hair cells
Abstract Stereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration. Dur...
Probing stress and magnetism at high pressures with two-dimensional quantum sensors
Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma
Abstract Immune checkpoint blockade (ICB) has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but predictive biomarkers remain limited. Here, we use a time...
Hydrocarbothermal flow synthesis of carbon-supported small and dense high-entropy alloy nanoparticles as electrocatalysts
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
Abstract Metastasis is responsible for most cancer-related deaths. However, only a fraction of circulating cancer cells succeed in forming secondary tumours, indicating that adaptive...
In situ and remote observations of the ultraviolet footprint of the moon Callisto by the Juno spacecraft
Abstract Jupiter exhibits peculiar multiwavelength auroral emissions resulting from the electromagnetic interactions of Io, Europa, and Ganymede with the magnetospheric plasma flow. Characte...
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
Integrated lithium niobate photonic computing circuit based on efficient and high-speed electro-optic conversion
Support-tuned iridium reconstruction with crystalline phase dominating acidic oxygen evolution
Abstract The dynamic reconstruction of oxygen evolution electrocatalysts dictates their performance, yet conventional Ir-based materials face an inherent activity-stability trade-off due to...
Ultrahigh pressure compaction-resistant thin film crosslinked composite reverse osmosis membranes
Abstract In this study, we present a class of thin-film crosslinked (TFX) composite reverse osmosis (RO) membranes that resist physical compaction at ultrahigh pressures (up to 200 bar). Sin...
Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity
Abstract Synaptic connectivity during development is known to require rapid local regulation of axonal organelles. Whether this fundamental and conserved aspect of neuronal cell biology is o...
SlimVar for rapid in vivo single-molecule tracking of chromatin regulators in plants
Abstract Epigenetic regulation occurs over many rounds of cell division in higher organisms. However, visualisation of the regulators in vivo is limited by imagi...
High-sensitivity and fast-response solar-blind photodetectors via band offset engineering for motion tracking
Catalytic aromatic C−H borylation via strained Si and Ge metallacycles
Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activation
Abstract Multiple myeloma (MM) is the second most common hematological malignancy that displays diverse genetic heterogeneity leading to treatment resistance. Recurrent mutations causing hyp...
Towards ultra-sensitive and rapid near-source wastewater-based epidemiology
Abstract Wastewater-based epidemiology is emerging as a powerful early-warning public health surveillance tool. However, gold-standard PCR necessitates transporting samples to laboratories,...
Lanthanum-assisted lattice anchoring of iridium in Co3O4 for efficient oxygen evolution reaction in low-iridium water electrolysis
Machine learning climbs the Jacob’s Ladder of optoelectronic properties
Abstract The use of machine learning (ML) as a powerful tool for the prediction of optoelectronic properties is still hampered by the inadequate level of the calculated training datasets, wh...