Nature Communications
Articles in this Issue
Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study
Abstract Childhood maltreatment effects on cerebral gray matter have been frequently discussed as a neurobiological pathway for depression. However, localizations are highly heterogeneous, a...
A mesothelial differentiation gateway drives fibrosis
Evolutionary history of ponerine ants highlights how the timing of dispersal events shapes modern biodiversity
Harms of introduced large herbivores outweigh benefits to native biodiversity
Abstract Introduced species significantly impact native biodiversity worldwide, with extensive research on harms but relatively less focus on benefits. Here, using the IUCN Environme...
Q&A Translational Cancer Nanomedicine
Multicolor fate mapping of microglia reveals polyclonal proliferation, heterogeneity, and cell-cell interactions after ischemic stroke in mice
Abstract Microglial proliferation is a principal element of the inflammatory response to brain ischemia. However, the precise proliferation dynamics, phenotype acquisition, and functional co...
Warming induces unexpectedly high soil respiration in a wet tropical forest
Abstract Tropical forests are a dominant regulator of the global carbon cycle, exchanging more carbon dioxide with the atmosphere than any other terrestrial biome. Climate models predict unp...
Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
Abstract The multifunctional protein gephyrin clusters inhibitory receptors at the postsynaptic membrane in the CNS. Gephyrin has been proposed to form the inhibitory postsynaptic de...
Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk
Climate research in the Global South
Operando interlayer expansion of multiscale curved graphene for volumetrically-efficient supercapacitors
Directing selective solvent presentations at electrochemical interfaces to enable initially anode-free sodium metal batteries
A retrospective cohort study of valproate and infertility in men with epilepsy or bipolar disorder using international health data
Abstract Valproate is highly effective at treating epilepsy and bipolar disorder. It faces prescribing restrictions in men due to concerns it causes testicular dysfunction and infertility. T...
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor
Abstract The P2X7 receptor is an ATP-gated ion channel that activates inflammatory pathways involved in diseases such as cancer, atherosclerosis, and neurodegeneration. However, despite the...
Author Correction: Causal disentanglement for single-cell representations and controllable counterfactual generation
Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics
Abstract Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development. The first step in re...
Greenland ice sheet runoff reduced by meltwater refreezing in bare ice
Abstract The contribution of Greenland Ice Sheet meltwater runoff to global sea-level rise is accelerating due to increased melting of its bare-ice ablation zone. There is growing evidence,...
Flexynesis: A deep learning toolkit for bulk multi-omics data integration for precision oncology and beyond
Abstract Accurate decision making in precision oncology depends on integration of multimodal molecular information, for which various deep learning methods have been developed. However, most...
Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development
Abstract Trophoblast organoids can provide crucial insights into mechanisms of placentation, however their potential is limited by highly variable extracellular matrices unable to reflect in...
Tastes and retronasal odours evoke a shared flavour-specific neural code in the human insula
Abstract During food consumption, tastes combine with retronasal odours to form flavour, which leads to a link so robust that retronasal odours can elicit taste sensations without co...
The reference genome of the human diploid cell line RPE-1
Meltwater ponding has an underestimated radiative effect on the surface of the Greenland Ice Sheet
Asymmetric coordination enhances the synergy of Pt species dual active sites for efficient photocatalytic H2 evolution
Heterogeneous, temporally consistent, and plastic brain development after preterm birth
Abstract The current view of neurodevelopment after preterm birth presents a strong paradox: diverse neurocognitive outcomes suggest heterogeneous neurodevelopment, yet numerous brai...
Social exposome and brain health outcomes of dementia across Latin America
Abstract A multidimensional social exposome (MSE)—the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more—may sh...