Nature Communications
Articles in this Issue
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank
Abstract Bone marrow adiposity changes in diverse diseases, but the full scope of these, and whether they are directly influenced by marrow adiposity, remains unknown. To address thi...
PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
Abstract PBK/TOPK is a mitotic kinase implicated in haematological and non-haematological cancers. Here we show that the key haemopoietic regulators Ikaros and Aiolos require PBK-mediated ph...
The first emergence of unprecedented global water scarcity in the Anthropocene
NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice
Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation
Abstract Sjögren’s disease (SjD) is an autoimmune disease that causes salivary gland dysfunction due to immune-mediated destruction. While autoantibodies such as anti-SSA and anti-centromere...
Repeatability of protein structural evolution following convergent gene fusions
Abstract Convergent evolution of proteins provides insights into repeatability of genetic adaptation. While local convergence of proteins at residue or domain level has been characterized, g...
Author Correction: A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images
Author Correction: VITAP: a high precision tool for DNA and RNA viral classification based on meta-omic data
Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterialization
Multiple independent acquisitions of a metallophore-synthesis gene by plants through horizontal microbial gene transfer
Abstract The evolution of land plants is marked by major innovations enhancing their vegetative and reproductive fitness. Despite their extensive adaptations to terrestrial habitats, plants...
Multiple lines of evidence for a hypervelocity impact origin for the Silverpit Crater
Abstract An impact origin for Silverpit Crater, on the UK continental shelf, has been contested over the last two decades, with a lack of definitive evidence – traditionally petrogra...
Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide Y2 receptor regulate arrestin-3 recruitment
Abstract Previous efforts in delineating molecular mechanisms of G protein-coupled receptor (GPCR) activation have focused on transmembrane regions and ligand-receptor contacts of the extrac...
Ferroelectric-based Pockels photonic memory
Distinct solvation patterns of OH− versus H3O+ charge defects at electrified gold/water interfaces govern their properties
Abstract Understanding the solvation structures of OH − and H 3 O...
Detection of 85 new active subglacial lakes in Antarctica from a decade of CryoSat-2 data
Abstract Subglacial lake activity influences ice sheet flow, grounding line discharge and ice shelf basal melting. Although 146 active subglacial lakes have been detected in Antarctica via i...
Thalamus enables active dendritic coupling of inputs arriving at different cortical layers
Abstract Dendritic calcium action potentials (APs) enable the main output neurons of the cerebral cortex – pyramidal tract neurons (PTs) – to associate inputs that arrive at different cortic...
Genetic architecture of plasma metabolome in 254,825 individuals
Abstract Circulating metabolites are crucial to biological processes underlying health and diseases, yet their genetic determinants remain incompletely understood. Here, we investigate the g...
Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation
Author Correction: Chirality encoding in resonant metasurfaces governed by lattice symmetries
Hayabusa2 extended mission target asteroid 1998 KY26 is smaller and rotating faster than previously known
Evolution of short trichomes and long hairs on Nigella petals through co-option of bHLH and non-MIXTA MYB genes
Author Correction: Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Author Correction: Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition
The bactericidal FabI inhibitor Debio 1453 clears antibiotic-resistant Neisseria gonorrhoeae infection in vivo
Abstract Gonorrhoea is a prevalent sexually transmitted infection caused by the bacterial pathogen Neisseria gonorrhoeae. N. gonorrhoeae has demonstrated a remarkable capacity to evolve anti...
Risks of AI scientists: prioritizing safeguarding over autonomy
Abstract AI scientists powered by large language models have demonstrated substantial promise in autonomously conducting experiments and facilitating scientific discoveries across various di...