Nature Communications
Articles in this Issue
Circumpolar spread of avian influenza H5N1 to southern Indian Ocean islands
Abstract Since 2020, the outbreak of high pathogenicity avian influenza (HPAI) H5N1 virus clade 2.3.4.4b has turned into the largest documented panzootic 1,3. Here, we describe its arrival i...
Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-derived Langerhans cells
Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance
Abstract Long-term robust intracortical microelectrode (IME) neural recording quality is negatively affected by the neuroinflammatory response following microelectrode insertion. Thi...
Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial
Extending quantum-mechanical benchmark accuracy to biological ligand-pocket interactions
Abstract Predicting the binding affinity of ligands to protein pockets is key in the drug design pipeline. The flexibility of ligand-pocket motifs arises from a range of attractive a...
A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut
Atomic-resolution imaging reveals nucleus-free crystallization in two-dimensional amorphous ice on graphite
Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models
Guided phase transition for mitigating voltage hysteresis of iron fluoride positive electrodes in lithium-ion batteries
Abstract Despite the high capacity attained by conversion-reaction-based metal-fluoride positive materials in lithium-ion batteries through multiple electron sto...
Disentangling climate and policy uncertainties for the Colorado River post-2026 operations
Abstract Lakes Mead and Powell in the Colorado River Basin underpin water and hydropower supply for the western United States. While the policies currently regulating the basin will...
Electron shuttling promotes denitrification and mitigates nitrous oxide emissions in lakes
Abstract Eutrophication is an emerging global issue that is becoming increasingly severe due to the rising nutrient inputs and limited availability of electron donors for nitrogen removal. I...
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup
Reply to: Giant virus genomes are unlikely to be reservoirs of antibiotic resistance genes
Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein
Abstract Liquid-liquid phase transitions govern a wide range of protein-protein and protein-RNA interactions. Although the importance of multivalency and protein disorder in driving these tr...
Solving the many-electron Schrödinger equation with a transformer-based framework
Biomimetic organo-hydrogels reveal the adipose tissue local mechanical anisotropy regulates ovarian cancer invasion
Abstract High-grade serous ovarian cancer, the most common and aggressive ovarian cancer subtype, frequently metastasises to visceral adipose tissues. In these tissues, the extracellular mat...
Ultrafast space-time optical merons in momentum-energy space
Impact of vaccination timing and coverage on measles near elimination dynamics: a mathematical modelling analysis
Abstract The Joint Committee for Vaccination and Immunisation recommended to implement an earlier second dose for the Measles-Mumps-Rubella (MMR) vaccine starting in 2026 in the United Kingd...
An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trial
HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques
Abstract Simian or Human immunodeficiency virus (SIV or HIV) vaccines based on V1-deleted envelope virus-like particles, delivered by the DNA/ALVAC platforms, followed by the ΔV1gp120 boost...
Constructing artificial neurons with functional parameters comprehensively matching biological values
GM-CSF-dependent CD301b+ mouse lung dendritic cells confer tolerance to inhaled allergens
Abstract The severity of allergic asthma is driven by the balance between allergen-specific T regulatory (Treg) and T helper (Th)2 cells. However, it is unclear...
A Bayesian decision support system for automated insulin doses in adults with type 1 diabetes on multiple daily injections: a randomized controlled trial
Abstract Achieving optimal glycemic control remains challenging for many individuals with type 1 diabetes using multiple daily injections. We report results from...
Genetic controllers for enhancing the evolutionary longevity of synthetic gene circuits in bacteria
Abstract Engineered gene circuits often degrade due to mutation and selection, limiting their long-term utility. Here we present designs for genetic controllers which maintain synthetic gene...