Nature Communications
Articles in this Issue
Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice
Abstract Spinal muscular atrophy (SMA) results from a deficiency of the survival motor neuron (SMN) protein. Zolgensma, an adeno-associated virus (AAV)-based...
Human RNA polymerase III termination favors decomposition over facilitated recycling
Astrocyte activation in the ventrolateral medulla modulates breathing and arousal states
Counterfactual evaluation of elementary and secondary school policies in the COVID-19 pandemic
A polymer-coated nanowire sponge–based contact electrocatalytic system for simultaneous disinfection and removal of multiple micropollutants
Trainable neuromorphic spintronic hardware Via analog finite-difference gradient methods
ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer
Realization of a chiral photonic-crystal cavity with broken time-reversal symmetry
Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells
Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrotic remodeling of the skin and internal organs. Fibrotic tissue changes are consider...
RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease
Abstract RBM20 is a cardiac splicing regulator whose dysfunction causes severe cardiomyopathies. Here, we uncover an unexpected layer of RBM20 regulation through a previously unrecog...
One-dimensional CsPbBr3 superlattices with polarized and amplified spontaneous circularly polarized emissions
Abstract Nanocrystal superlattices typically occur in two- or three-dimensional configurations, constrained to the micrometer scale and with limited size tunabil...
PD-1 regulates latent effector differentiation of thymic cytotoxic CD8+ T cells
Abstract Durable T cell immunity against cancer depends on the continual replenishment of effector CD8⁺ T cells. Thymic output has been associated with favorable prognosis in cancer...
Interfacial dipolar interactions drive giant second-harmonic generation in 2D organic–inorganic heterostructures
Macrophage-derived fibronectin suppresses antitumor immunity via tissue stiffening and immunosuppressive cell induction in cancer mouse models
Abstract Both tumor-associated macrophage (TAM) and tumor stiffness may support immunosuppression and limit immunotherapy response, particularly in non-small cell lung cancer (NSCLC)...
Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions
The current Ebola outbreak is a public health emergency of international concern
Structural basis of signal peptide recognition by the signal peptidase complex
Abstract The signal peptidase complex (SPC) is responsible for cleaving signal peptides (SPs) from approximately 10% of the human proteome. SPs are characterized by a tripartite stru...
PATTY corrects open-chromatin bias for improved bulk and single-cell CUT&Tag profiling
A scalable Tn5-based method for genome-wide DNA methylation profiling in development and disease
Abstract DNA methylation is a key epigenetic modification involved in development and disease, including cancer, and serves as a biomarker for diagnosis. Current...
Ancient DNA reveals a family ossuary and long-distance migration on the Pacific coast before the Inca Empire
Abstract This paper tracks long-distance migration on the Pacific coast that began no later than the thirteenth century AD. Genome-wide data for 21 sampled indiv...
Recognition and silencing of a new transposable element
Observation of Kondo cloud-coupling in a mirror-symmetric carbon nanotube array-molybdenum structure
Interfacial W–O–Zr ensembles in tungstated zirconia catalysts enable efficient hydrogen-free recycling of polypropylene waste
Abstract Polyolefins are essential plastics to modern life yet create mounting sustainability challenges. Chemical recycling technologies are key but often requi...
Cryo-EM structures of ALECT2 filaments from human renal biopsies
Abstract Leukocyte chemotactic factor 2 is a recently identified amyloidogenic protein, whose abnormal aggregation defines a systemic amyloidosis termed ALECT2 amyloidosis. Due to th...