Nature Communications

Concise synthesis of chiral tricyclic γ-lactams via synergistic isothiourea/Ir catalyzed asymmetric [3 + 2] annulation

Gaussian curvature engineering of self-pressurizing mesoporous nanoreactors boosts dynamic equilibrium of molecule adsorption-desorption

Temporal trends in evidence supporting novel drug target discovery

Abstract Over the past decade, about one-fifth of FDA-approved drugs each year involve novel mechanism-of-action human targets. Although riskier than modulating well-known targets, t...

EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection

Abstract Mutations in the global transcriptional activator EP300/KAT3B are being reported in aggressive malignancies. However, the mechanistic contribution of EP300 dysregulation to...

Steroid hormone receptors through Cry2 are key players in the circadian clock response to serum

Molecular competition induced Janus hydrogel bioelectronic interface for electroceutical modulation

Abstract Janus hydrogel bioelectronic interfaces have long been challenged by complex fabrication procedures, poor controllability of asymmetric properties and weak interlayer bondin...

CMIP6 models cannot capture long-term forced changes in the tropical Pacific sea surface temperature gradient

Subsurface engineering for directional-selective CO₂-to-ethanol electrocatalysis at industrial-level

Thermal conductivity modeling beyond the dilute limit using a body-centered cubic framework for densely packed polymer composites

Sharp spectroscopic fingerprints of disorder in an incompressible magnetic state

Harnessing theta-gamma coupled brainwaves using ultrasound for spinal astrocyte revitalization and sustained neuropathic pain relief in mice

Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice

A next-generation dual guide CRISPR system for genetic interaction library screening

Abstract Pairwise perturbation of gene function using the CRISPR/Cas9 system has potential in screening for genetic interactions and synthetic lethal gene pairs...

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies

NiFe2O4 spinel engineering for transcending the dilemma of activity–selectivity in CO2 hydrogenation to ethanol

Anti-swelling and self-activating artificial proteoglycan assemblies as cartilaginous implant for post-microfracture healing

Worldwide trends in metabolic syndrome from 2000 to 2023: a systematic review and modelling analysis

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Interacting filaments drive vesicle morphogenesis

VIRGO2: an enhanced gene catalog of the vaginal microbiome provides insights into its functional and ecology complexity

Constructing out-of-plane oriented two-dimensional covalent organic framework films for stretchable electronics

Temporally resolved and interpretable machine learning model of GPCR conformational transition

Abstract Identifying target-specific drugs remains a challenge in pharmacology, especially for highly homologous proteins such as dopamine receptors D...

Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities

In-situ entropic ligand engineering enables high-efficiency quantum dot solar cells

Divergent resource limitations of belowground versus aboveground productivity across grasslands