Nature Communications
Articles in this Issue
Fragment-based discovery enables direct targeting of the melanoma oncogene MITF
Primary material supply configurations and domestic recycling for cost-effective battery material production in the US
Abstract Battery cathode active material costs hinge on regionally concentrated, price-volatile metal supply. Here. we construct a regional facility-level cost model based on over 80...
Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
Abstract The development of selective ligands to target DNA G-quadruplexes (G4s) and i-motifs (iMs) has revealed their relevance in transcriptional regulation. H...
Implementing N-terminomics and machine learning to probe Nt-arginylation
An astrocytic ensemble at vHip-NAc synapses modulates cognitive impairments induced by chronic tetrahydrocannabinol exposure
Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration
Quantum-inspired superposition and nonseparable states of reconfigurable metasurfaces in classical systems
Self-driving lab discovers principles for steering spontaneous emission beyond conventional Fourier optics
Abstract We develop an autonomous experimentation platform to accelerate interpretable scientific discovery in ultrafast nanophotonics, targeting a novel method to steer spontaneous...
A Pseudomonas aeruginosa quorum-sensing inducer controls lung permeability in establishing chronic infection via EGFR
Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths
Abstract Using the Telomere-to-Telomere reference, we assemble the distribution of simple tandem repeat lengths present in the human genome. Analyzing over three hundred mammalian ge...
Multi-state detection and spatial addressing in a microscope for ultracold molecules
Abstract Precise measurement of the particle number, spatial distribution and internal state is fundamental to all proposed experiments with ultracold molecules...
Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139
Abstract The orphan G protein-coupled receptor (GPCR) GPR139 attracts interest as a target for neuropsychiatric disorders. Whereas the physiological functions of GPR139 remain elusiv...
Carbon markets promote environmental justice in China
Reactant-dependent volcano trends in Pt-catalyzed cycloalkane dehydrogenation: orbital hybridization-guided design of active sites
Abstract Catalyst design is often reaction-specific due to the lack of universal descriptors linking molecular structures to optimal active-site configurations....
Distinct structural features of Pseudomonas aeruginosa ATP synthase revealed by cryo-electron microscopy
Abstract F 1 F o ATP synthase is the ubiquitous enzyme that synthesizes cellular...
Extremely cold ocean temperatures in iron formation brine pools of snowball Earth
Abstract For the severe low-latitude “snowball Earth” glaciations, glacial deposits occurring on all continents is well-established. However, cold, salty, ice-co...
Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis
An outer membrane vesicle vaccine prevents lung pathology in a macaque model of pneumonic melioidosis
pH-dependent mechanism of oxygen evolution in highly disordered RuO2 nanosheets
The rise and global spread of IMP carbapenemases (1996-2023): a genomic epidemiology study
Abstract Infections caused by carbapenemase-producing organisms are a global health threat. IMP carbapenemases are one of the key drivers of these infections but...
Intrinsically flexible multimode reconfigurable transistors for polymorphic circuits and neuromorphic devices
Abstract Reconfigurable transistors hold considerable significance for both integrated circuits and neuromorphic electronics. At the same time, flexible electronics is developing rap...
Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex
Dual-photon–driven hydrogen evolution in copper-based photocatalysts under near-infrared and visible light
Multiplexed detection of febrile infections using CARMEN
Abstract Detection and diagnosis of bloodborne pathogens are critical for patients and for preventing outbreaks, yet challenging due to these diseases’ nonspecif...