Nature Communications
Articles in this Issue
Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer
Abstract The role of RNA N 6 -methyladenoine (m 6 A) eraser AlkB homologue 5 (ALK...
Flexible read-aware genotype imputation from sequence using biobank sized reference panels
Abstract Inexpensive and accurate genotyping methods are essential to modern genomics and health risk prediction. Here we introduce QUILT2, a scalable and read-aware imputation metho...
Gain engineering and atom lasing in a topological edge state in synthetic dimensions
Abstract Recent advances in quantum technology have highlighted the importance of controlling quantum states, especially in open quantum systems, where the system interacts with the...
Cost-effective non-additive GWAS across 2329 diseases in 500,349 individuals
Reshaping reservoirs with unsupervised Hebbian adaptation
Abstract Reservoir Computing (RC) is a lightweight way to model time-dependent data, yet its reliance on static, randomly initialized network architectures often limits performance o...
Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation
Enhanced piezo-photocatalytic water splitting activity via engineering robust dipole moments in covalent organic frameworks
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations
Abstract In spite of the growing interest in the microbiome in human cancer, there are currently only small-scale lung cancer microbiome studies conducted direct...
Electrifying long-haul freight trucks reduces societal costs in the United States
Abstract Electrifying long-haul heavy-duty vehicles (HDVs) entails high private costs but offers substantial reductions in external costs by substituting diesel combustion with elect...
Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels
Abstract Volume-regulated anion channels (VRACs) are ubiquitously expressed vertebrate ion channels that open in response to hypotonic swelling. VRACs assemble as heteromers of LRRC8...
Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease
Ultra-rapid preparation of large-area high-crystallinity covalent organic framework membranes
A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial
Abstract In this randomized, double-blind controlled trial, 182 Filipino children aged 2-3 years received either an experimental young child formula (EYCF) conta...
Atomically confined excitons in 2D perovskites for bright and sub-nanosecond scintillation
Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens
Abstract The degree of protection conferred after receiving an oral cholera vaccine (OCV) varies based on age, prior exposure to Vibrio chole...
Reactive nitrogen-driven atmospheric multiphase buffering induces unintended concomitant pollution
In-situ nano-reprecipitation enables superior cryogenic mechanical properties in a 3D printable medium-entropy alloy
In-sensor image memorization, low-level processing, and high-level computing by using above-bandgap photovoltages
Natural degradation of RNA polymerase II is essential for oocyte chromatin reorganization and maternal-to-zygotic transition
Asymmetric synthesis of stereogenic-at-sulfur compounds via biocatalytic oxidation with Unspecific Peroxygenases
Abstract Stereogenic-at-sulfur compounds are vitally important biologically active small molecules, with many drugs featuring chiral sulfur atoms. Methods for th...
Photoredox-controlled alternating copolymerization enables highly crystalline structures and block copolymers from thermoplastic to elastomer
Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration
Wireless battery-free ultrathin lithium-niobate resonator as wearable and implantable electronics for continuous monitoring of mechanical vital signs
Hic-5 drives epithelial mechanotransduction promoting a feed-forward cycle of bronchoconstriction
Abstract Mechanical forces are essential for organ function, but excessive or dysregulated forces can promote pathologic conditions. In asthma, bronchoconstriction narrows the airway...