Nature Communications
Articles in this Issue
Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
Abstract Arthrogryposis, Renal dysfunction and Cholestasis (ARC) syndrome is a rare inherited disorder caused by defects in the VPS33B trafficking protein, leading to impaired bile f...
Ultranarrow nanochannels in a staggered two-dimensional polymer membrane enhance electric double-layer coverage for osmotic energy harvesting
Abstract Two-dimensional framework membranes (2DFMs) hold great promise for sustainable energy-harvesting technologies, yet their performance is often limited by...
Engineered halohydrin dehalogenase mediates remote enantiocontrolled dehalogenative hydroxylation via an unconventional mechanism
Entropy-driven order-to-disorder transition in perovskite anodes for high-performance solid oxide fuel cells
Abstract Solid oxide fuel cells (SOFCs) enable direct and efficient conversion of transportable hydrocarbons into electricity, offering a scalable pathway for ca...
Impact of the local valley splitting on the coherence of conveyor-belt spin shuttling in 28Si/SiGe
Abstract Electron spins in silicon offer a promising path toward scalable, fault-tolerant quantum computing, with the potential to host millions of qubits. Howev...
Koopman global linearization of contact dynamics for robot locomotion and manipulation enables elaborate control
Abstract Controlling robots that dynamically engage in contact with their environment is a pressing challenge. Whether a legged robot making-and-breaking contact with a floor, or a m...
Fully-connected microwave photonic multi-beamformer with fast beam-steering for broadband wireless communication
Gradient-distributed metal-halide dynamic memristors for adaptive and robust voiceprint recognition
Paleorecords inform the limits of Indo-Pacific coral reef survival under accelerating sea-level rise
All-2D vertical metal-semiconductor field-effect transistor with sub-10 nm channel and contact lengths
Conformational cycling of the Wntless transporter drives trafficking and secretion of Wnt morphogens
Abstract Wnt proteins are lipid-modified morphogens fundamental in development and disease. During Wnt biogenesis, the G-protein-coupled receptor (GPCR)-like transporter Wntless (WLS...
Molecular mechanisms of transhydrogenase activity and allosteric regulation in eukaryotic type II PHGDH Ser33
Abstract L-serine is a critical structural constituent of proteins and membrane phospholipids, playing major roles in cell signaling, metabolism and development....
A domestication gene links plant architecture and nitrogen metabolism to enhance yield in foxtail millet
Scaling covalent ligand discovery through dynamic combinatorial library-versus-proteome screening
Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer
Enabling high-voltage aqueous dual-ion batteries capable of working at −40 °C in a low-concentration salt electrolyte
Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis
A cyclin-polarity feedback network ensures healthy cell proliferation
Abstract Healthy proliferation requires the coordination of cell cycle progression with cell polarity. In budding yeast, polarity is established when G1-cyclin-C...
Scalable, fast and accurate differential gene expression testing from millions of cells of multiple patients
Abstract Since the development of DNA microarrays and later RNA bulk sequencing, testing with statistically independent samples has been the standard method for detecting genes with...
Erosion-driven delayed warming and marine stress prior to the end-Permian mass extinction
Volatile anaesthetics modulate voltage-gated sodium channel function at a site directly linked to channel gating
Large-scale genomic surveillance reveals immunosuppression drives mutation dynamics in persistent SARS-CoV-2 infections
Abstract Persistent SARS-CoV-2 infections have been hypothesized to play a key role in the emergence of variants of concern. However, the factors determining which individuals are at...
Neuron-targeting piezoelectric microneedles disrupt pro-tumorigenic neuron-immune crosstalk and restore anti-tumor immunity in melanoma
The post-fertilization archegonium gene network of seedless plants contributed to the origin of seeds
Abstract The evolution of seeds was a critical transition in plant evolution, but how ancestral seedless development was modified to form the first seed is only...
Paramagnetically driven superconducting re-entrance in Eu-doped infinite layer nickelates
Abstract The breakthrough discovery of superconductivity in infinite-layer nickelates, and subsequently in several superconducting nickelates with more complex l...