Engineered halohydrin dehalogenase mediates remote enantiocontrolled dehalogenative hydroxylation via an unconventional mechanism

X Xiao Jin H Hai-Xia Zhang (State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences) K Kui-De Lu Z Zhang-Yang Wang H Hui-Hui Wang Y Yong-Zheng Chen (Key Laboratory of Innovation and Manufacturing for Pharmaceuticals of Guizhou Province, Key Laboratory of Basic Pharmacology of Ministry of Education, School of Pharmacy) N Nan-Wei Wan

Article Details

Volume / Issue Vol. 17, Issue 1
Published June 19, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (7)

X

Xiao Jin

H

Hai-Xia Zhang

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences

K

Kui-De Lu

Z

Zhang-Yang Wang

H

Hui-Hui Wang

Y

Yong-Zheng Chen

Key Laboratory of Innovation and Manufacturing for Pharmaceuticals of Guizhou Province, Key Laboratory of Basic Pharmacology of Ministry of Education, School of Pharmacy

N

Nan-Wei Wan