Nature Communications
Articles in this Issue
Single-crystal growth of complex non-fullerene acceptor molecules via cocrystallization
Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response
Abstract Tumour-induced mechanisms of immune evasion hinder immune response to cancer, particularly in melanoma. mRNA translation, by ensuring accurate protein s...
Highly selective and practical hydrogenation of functionalized (hetero)arenes
Interplate rheological contrast revealed by asymmetric deformation after the 2023 Kahramanmaraş earthquakes
The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells
Abstract DNA repair genes are generally considered tumor suppressors, as their inactivation is observed in tumors and is associated with carcinogenesis. Mutations in BRCA1 and BRCA2...
Target-stabilized base editors enable robust high-fidelity RNA editing
Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells
Abstract Proteolytic cleavage of proglucagon by prohormone convertase 2 (PC2) is required for islet α cells to generate glucagon. However, the regulatory mechanisms underlying this p...
Eliminating the negative pore synergy in hierarchical porous metal-organic frameworks for isomer separation
Electrolyte diluent with large electrostatic potential difference for fast charging and slow discharging lithium metal batteries
Maximizing energy utilization and lithium leaching efficiency via sequential electrochemical dual-oxidation and soaking-relaxation
Abstract Given the escalating global demand for lithium resources, optimizing electric energy consumption in the electrochemical dual-oxidation (EDO) process, wh...
Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans
Abstract Animals integrate internal states to guide survival-critical decisions, but whether and how intestinal bacteria influence this process by interacting wi...
Strategies for synergistic reduction of plastic leakage and greenhouse gas emissions in China
Abstract The plastics industry is now confronting the intertwined challenges of environmental leakage and greenhouse gas emissions. Although policy interventions may exert synergisti...
Responsive interlayer spacing in staggered metal-organic framework nanosheet membranes
Methanoperedenaceae archaea: a 20-year research journey
Developmental underpinnings of morphological disparity in the avian bony palate
A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function
Abstract Mitochondria maintain a distinct biochemical environment that cooperates with pro-apoptotic BAX and BH3‑only proteins (e.g., BIM) to promote mitochondri...
Graded phononic metamaterials based on scalable microfabrication and design
Abstract Metamaterials’ engineered internal structures enable customized material properties beyond those found in nature, such as the capability to guide, attenuate, and focus waves...
Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula
Abstract Accurate internal estimates of self-motion and orientation relative to gravity are fundamental for stabilizing gaze, controlling posture, and navigating through dynamic envi...
ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks
Abstract DNA double-strand breaks (DSBs) both pose threats to genome integrity and are commonly used for genome editing applications. Structural features of DSB...
Idiotype-specific CD4+ T cells chronically stimulate autoreactive B cells to develop into B lymphomas in mice
Abstract Autoimmunity increases the risk of developing B lymphoma in humans; however, the molecular mechanism(s) underlying this link remain(s) unexplained. Here...
Copper-catalysed dynamic kinetic (4+1) cyclization of 1,3-enynes for atroposelective arylpyrrole synthesis
Rising Air-Conditioning Use Intensifies Global Warming
Solvation chemistry tailored via dielectric constant engineering for stable low-temperature aqueous zinc batteries
Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes
Abstract The appearance of diabetes-associated autoantibodies is the first detectable sign of the disease process leading to type 1 diabetes (T1D). Evidence suggests that T1D is a he...