Nature Communications
Articles in this Issue
Human-like cognitive generalization for large models via mental representation-guided supervision
Reversible color switching of bright phosphorescence in purely organic materials for advanced data encryption
Structural and functional dissection of a higher-order oligomerization interface in yeast ceramide synthase
Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models
Abstract Adoptive T cell therapy (ACT) is effective against hematologic cancers, but the mechanisms underlying durable responses in solid tumors remain unclear....
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia
Single-breath-hold 3D abdominal metabolic MRI enables label-free diagnosis of liver cancer
Abstract Chemical exchange saturation transfer (CEST) MRI could detect proteins/peptides, creatine, glucose, and glycogen by labeling their exchangeable amide, a...
Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components
Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs
Single-cell phenotypic heterogeneity shapes quorum signaling dynamics in Pseudomonas aeruginosa
Triggering dynamically disordered lithium sublattice in superionic conductors
Strong nickel enrichment co-located with redox-organic interactions in Neretva Vallis, Mars
Sialic acid exacerbates polycystic ovary syndrome in mice by modulating gut microbiota-mediated bile acid metabolism and FXR activation
Small intestinal microbial fiber metabolism dysfunction in celiac disease
Theoretical morphospace reveals mixed optimisation of the avian wing planform for flight style
Abstract Bird wings exhibit a broad degree of functional and shape variation, though the exact nature of the form-function relationship is uncertain. Recent analysis suggests that fu...
Lattice strain-mediated MoSe2 enable superior piezocatalysis activity for upcycling of organic pollutants
Flexible active-matrix micro-LED display with 1T-1FeMFET architecture featuring scaling-limit-free design
Abstract The advancement of flexible electronics necessitates displays that combine bendability, high resolution, and energy efficiency. Nevertheless, convention...
Emergent surface magnetic ordering and surface electronic dipole layers in a two-dimensional spin=1/2 La2CuO4 film
PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma
The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons
Abstract The N-terminal acetyltransferase B (NatB) acetylates ~20% of the eukaryotic proteome. However, the role of NatB-mediated N-terminal acetylation (NTA) fo...
Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions
Abstract White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence sugge...
Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter
Abstract ATP-binding cassette (ABC) transporters are molecular machines involved in diverse physiological processes, including antigen processing by TAP, a key c...
CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever
A statistical understanding of oxygen vacancies in distorted high-entropy perovskite oxides
Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing
Abstract Ribosome biogenesis requires the synthesis and sequential processing of precursor rRNAs (pre-rRNAs) into mature rRNAs. Traditional methods such as northern blotting and meta...