Nature Communications
Articles in this Issue
Long-term nitrogen burial exceeds denitrification in global fjords
Abstract Nitrogen (N) availability regulates primary productivity and hence directly affects global oceanic carbon sequestration. Global fjords account for up to 11% of marine carbon...
Accelerated drug development using a digital formulator and a self-driving tableting data factory
Abstract Advances in drug discovery and clinical research have shifted the bottleneck in medicines development to chemistry, manufacturing, and controls activities, a critically step...
Clinicopathologic and molecular predictors of survival in BRCA-deficient tubo-ovarian high-grade serous carcinoma
Abstract BRCA -associated homologous recombination deficiency (HRD) is present in ~50% of high-grade serous carcinomas (HGSC) and predicts se...
The genetic architecture of an allosteric hormone receptor
FSHR and LHR functional compensation reveals the mechanism and treatment of Ovarian Hyperstimulation Syndrome
Miniature and versatile genome regulation TnpB-ωRNA toolkits facilitate cancer immunotherapy
Light-induced bimerons in a chiral magnet
Interplay of SLC33A1-dependent and -independent Golgi sialic acid O-acetylation in CASD1 catalysis
Abstract Sialic acid O -acetylation is implicated in the modulation of sialoglycan recognition and ganglioside biology. T...
Atomic-scale reconstruction of sapphire induced by selective tribochemical removal of surface atoms
Synthesis of atomically dispersed catalysts via hydrogen embrittlement-like assisted thermal activation for acidic oxygen reduction
Wavelength-responsive in situ redox chemistry enables stable CO2 photocatalysis
Sgk1 upregulation in hippocampus-projecting amygdala neurons underlies the delayed onset of PTSD-like avoidance behavior
Abstract Excessive avoidance is a core symptom of post-traumatic stress disorder (PTSD), yet its underlying circuit mechanisms remain poorly understood. Here, using a mouse model of...
Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER+ HER2− locally-advanced or metastatic breast cancer
Abstract Next-generation selective estrogen receptor-α (ERα) antagonist/degraders (SERDs) are being developed for ER-positive breast cancer (ER...
TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation
Abstract Gastrointestinal dysfunction often precedes motor symptoms in Parkinson’s disease (PD), suggesting the enteric nervous system (ENS) is central to early pathogenesis. How α-s...
Reentrant superconductivity in a naturally occurring Josephson junction array tuned by radio-frequency power
Glass scallop genome reveals key adaptations to deep-sea environments and ectosymbiosis
Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still’s disease
Abstract Autoinflammation of unknown origin remains amongst the most enigmatic of systemic autoinflammatory disorders (SAID), with systemic autoinflammatory symptoms in the absence o...
Deciphering the Hidden Ecology and Connectivity of Vibrio in the Oceans
Abstract Long-range dispersals of marine bacteria in the oceans have remained largely indecipherable, which is particularly relevant for Vibr...
Pillar[5]arene-catalyzed anti-Markovnikov halogenations through cationic intermediates stabilization in confined spaces
Abstract The confinement of reactants within catalytic cavities is important for achieving efficient and selective chemical transformations. Macrocyclic organic...
Bidirectional yet asymmetric causality between urban systems and traffic dynamics in 30 cities worldwide
Abstract Understanding how urban systems and traffic dynamics co-evolve is crucial for advancing sustainable and resilient cities. However, their bidirectional causal relationships r...
Single-event fast neutron time-of-flight spectrometry with a petawatt-laser-driven neutron source
Abstract Laser-driven neutron sources (LDNSs) offer unique advantages for fundamental physics and applications: ultrashort pulses providing superior energy resol...
Disulfide modification and thiol protection via tris(trimethylsilyl)silane-mediated hydrosilylation of disulfides
Abstract Thiol functionalities are indispensable in both biological and synthetic chemistry. However, unlike the powerful silylation strategies for hydroxyl groups, widespread applic...
Recombinant haemostatic protein for therapeutic substitution of platelet function via tripartite haemostatic mechanisms in thrombocytopenic male mice
Quantifying yield losses from Bt resilience among maize cultivars in South Africa
Abstract Genetically modified crops have provided economic and social benefits since becoming commercially available. One of the most successful and widely used...
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
Abstract Horizontal gene transfer plays a key role in bacterial evolution, yet its efficiency under natural conditions, especially between genetically distinct s...