Nature Communications
Articles in this Issue
High-resolution mapping reveals features of bacterial NAD-capped RNAs and stress-responsive transcription initiation
Dissecting PGE2-driven inhibition of T cell activation using single-cell multi-omic and inflammatory bowel disease genetic association analysis
ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence
African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children
Abstract Iron is essential for both humans and pathogens, yet its genetic regulation remains understudied in African populations. Here, we report genome-wide ass...
Cryo-EM structure of a photosystem I supercomplex from Euglena gracilis containing pentameric LHCE and dimeric LHCII
Ancestral functionality and symbiotic refinement of NIN in root nodule symbiosis
Abstract Nitrogen-fixing nodule symbiosis is an ecologically and economically important trait in legumes and some related species. A critical step in the evolution of nodulation is t...
Solution epitaxy of single-crystal ferroelectric p-i-n structure with ultrahigh photovoltaic response
Structural insights into single-pass transmembrane receptor GC-A activation by distinct antihypertensive antibodies
Genetic architecture of lumbar spinal stenosis
Nickel-catalyzed ring-opening difunctionalization of methylenecyclobutanes via strain-release-enabled C-C activation
In vivo CAR T cell generation using retargeted and functionalized lentiviral vectors with reduced immunogenicity
Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging
Abstract Hematopoietic stem cells (HSCs) survive many types of cellular stress but often lose their regenerative and lymphopoietic capacities as a result. Such functional decline als...
Structural and mechanistic basis for antibody neutralization of the measles fusion protein
CellLoop: Identifying single-cell 3D genome chromatin loops
Comprehensive CRISPR/Cas9-based mutagenesis identifies single-amino acid substitutions that abrogate SPEN function in X inactivation
Abstract While genetic screens have facilitated the dissection of protein function in animal development, advances in systematic point mutagenesis open new oppor...
Bacterial extracellular vesicles as recyclable nutrient reservoirs
Abstract Bacterial extracellular vesicles (EVs) are known to mediate intercellular communication, virulence, and immune modulation. Here we show that bacteria ca...
Demographic causes and social consequences of adult sex ratio variation
Abstract The adult sex ratio plays a crucial role in shaping breeding systems and traits linked to sexual selection. Recent studies associate adult sex ratio with mate choice, pair-b...
VPS26A retromer complex and SNX27 mediate stress-induced Golgi bypass of membrane proteins
B cell immunity to the Lassa virus glycoprotein is a correlate of vaccination-induced virus control in mice
Abstract Lassa fever, a viral hemorrhagic fever caused by the arenavirus Lassa virus (LASV), affects thousands of individuals annually, highlighting the need for a vaccine. Yet, immu...
Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial
Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia
Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors
Abstract The GAIN domain is a hallmark of adhesion G protein-coupled receptors (aGPCRs), as this extracellular domain contains an integral agonistic sequence (...