ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence

Mengjie Li; Mibo Tang; Xiaoyan Hao; Zhengwei Hu; Dongrui Ma; Shuangjie Li; Chunyan Zuo; Zhiyun Wang; Yuanyuan Liang; Yanmei Feng; Chenwei Hao; Chen Wang; Huanyu Li; Yalan Yang; Yuemeng Sun; Shasha Qi; Chengyuan Mao; Yuming Xu; Qun Wang; De Yang; Ruwei Yang; Ziyao Zhou; Peilin Ji; Song Tan; Zaiqiang Zhang; Hao Chen; Albert R. La Spada; Changhe Shi

doi:10.1038/s41467-026-71516-7

ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence

M Mengjie Li M Mibo Tang X Xiaoyan Hao Z Zhengwei Hu (Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions) D Dongrui Ma S Shuangjie Li C Chunyan Zuo Z Zhiyun Wang Y Yuanyuan Liang Y Yanmei Feng C Chenwei Hao C Chen Wang H Huanyu Li Y Yalan Yang (Department of Oncology, Beijing Shijitan Hospital, Capital Medical University) Y Yuemeng Sun S Shasha Qi C Chengyuan Mao Y Yuming Xu Q Qun Wang (State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research) D De Yang R Ruwei Yang Z Ziyao Zhou P Peilin Ji S Song Tan Z Zaiqiang Zhang H Hao Chen A Albert R. La Spada C Changhe Shi

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published April 07, 2026

DOI 10.1038/s41467-026-71516-7

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (28)

M

Mengjie Li

M

Mibo Tang

X

Xiaoyan Hao

Z

Zhengwei Hu

Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions

D

Dongrui Ma

S

Shuangjie Li

C

Chunyan Zuo

Z

Zhiyun Wang

Y

Yuanyuan Liang

Y

Yanmei Feng

C

Chenwei Hao

C

Chen Wang

H

Huanyu Li

Y

Yalan Yang

Department of Oncology, Beijing Shijitan Hospital, Capital Medical University

Y

Yuemeng Sun

S

Shasha Qi

C

Chengyuan Mao

Y

Yuming Xu

Q

Qun Wang

State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research

D

De Yang

R

Ruwei Yang

Z

Ziyao Zhou

P

Peilin Ji

S

Song Tan

Z

Zaiqiang Zhang

H

Hao Chen

A

Albert R. La Spada

C

Changhe Shi

ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage, 3D chromatin structural abnormalities, and senescence

Article Details

Journal Info

Authors (28)

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