Nature Communications
Articles in this Issue
Establishment of DNA methylation during primate germ cell development
Abstract DNA methylation is almost completely erased throughout the genome in primordial germ cells, and then reestablished during mammalian germ cell development. In this study, we...
A high-frequency silicon-graphene-germanium barristor
Skeletal editing via multi-step engineering of a modular polyketide synthase
Quantum circuit complexity and unsupervised machine learning of topological order
Abstract Enabling the discovery of unknown quantum many-body phases of matter remains a fundamental challenge in machine learning for quantum physics. Here, inspired by the close rel...
Scaling up Bayesian population phylogenomics through virtual dimension reduction
Swell-driven bursts of 26 s and 16 s seismic spectral peaks in the Gulf of Guinea
Nuclear waste radionuclides unveil three decades of anthropogenic carbon in the Canada Basin of the Arctic Ocean
Open questions in elucidating neural mechanisms underlying sensory-guided motor control
Massively parallel in-sensor skinomorphic computing
A principled basis for nonequilibrium network flows
De novo-designed ribozyme-controlled riboregulator for cell-free diagnostics
Abstract Cell-free systems have great potential for nucleic acid assays, yet universal onsite diagnostics without preamplification are limited. Here, a universal cell-free diagnostic...
Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial
Abstract In PREDIX LumB patients with estrogen receptor positive and human epidermal growth factor receptor negative (ER + /HER2-) breast cancer > 20 mm and/o...
Photochemical synthesis of oxiranes using DABSO-activated sulfinates and allylic peroxides
Bed nucleus of the stria terminalis connectivity during food cue and taste processing under stress
Intraocular pressure induced blood retinal barrier compromise in mouse models and human glaucoma
Activation mechanism and integrated one-pot assay of chiral-like cRNA-enhanced CRISPR/Cas12a systems
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial
Abstract Rapid vascular recovery is a key feature preceding glioblastoma (GBM) recurrence after radiotherapy (RT). We performed spatial expression analyses, prov...
Sequential ethane filling induced structural transitions in a flexible–robust metal–organic framework for ethylene purification
PD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer
Abstract While progenitor-exhausted T cells (Tpex) expressing TCF1 and PD-1 are crucial for the therapeutic effect of immune checkpoint inhibitors (ICIs) with th...
RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions
NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition
Bioinspired total synthesis of (+)-pleuromutilin
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis
Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro
Abstract Tissue homeostasis emerges from mechanical feedback loops balanced by cell loss and proliferation, a balance that in postmitotic tissues must be maintained without compensat...