Nature Communications
Articles in this Issue
Activating in-plane dead zones of anode catalyst layers in proton exchange membrane water electrolyzers
Abstract The utilization of iridium-based anode catalysts in proton exchange membrane water electrolyzers is largely limited by the presence of electrochemically...
Changes in El Niño–Southern Oscillation and global frequency entrainment
The Riemann Hypothesis manifested in dynamical quantum phase transitions
De novo EHMT2 variants cause an autosomal dominant EHMT2-related Kleefstra syndrome via loss of G9a methyltransferase activity
Abstract EHMT1 and EHMT2 genes encode human euchromatin histone lysine methyltransferase 1 and 2 (EHM...
Pre-existing antibody and T cell responses to SaCas9, AsCas12a and CasΦ are comparable in naïve individuals
Abstract Cas9 proteins are derived from human pathogens and are immunogenic, thereby raising potential safety concerns and limiting clinical effectiveness when u...
Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming
RNF2 mediates H2A ubiquitination to promote colitis via suppressing monocyte-macrophage transition in mice
Transposable elements impact the human regulatory landscape through cell type specific epigenomic associations
Alphavirus M1 disrupts super-enhancer-driven oncogenic transcription via non-structural protein NSP2 in osteosarcoma
Abstract Oncolytic virotherapy has shown promise for various cancers, but its application in osteosarcoma (OS) remains underexplored. This study provides evidence that M1, a natural...
Two-pore channel-2 controls calmodulin-dependent STIM1 inactivation
Abstract Lysosomal two-pore channels (TPC) trigger Ca 2+ release from the endoplasmic reticulum (ER). The ensuing ER Ca...
Molecular bridge engineering in covalent organic frameworks for enhanced electronic transport
The potential role of H2S in the anti-infective function of antimicrobial peptides
DNA hypomethylation enables the transcriptional repressor SlSPL-CNR to control fruit flavor ester biosynthesis
Abstract Reduction of DNA methylation has traditionally been associated with gene activation. Here, we show that DNA hypomethylation permits the binding of a tra...
Designing and mapping cascade catalysis pathway for balanced polysulfide conversion in Li-S batteries
Abstract Lithium–sulfur batteries are fundamentally constrained by the sluggish 16-electron sulfur reduction reaction. Electrocatalytic sulfur reduction reaction...
Structural basis for independent pore function of Vpb4 from Bacillus thuringiensis
Abstract The Bacterial_Exotoxin_B family constitutes translocating pore-forming proteins that function as the binding (B) component in the binary AB Toxin mechan...
Global inequality in roadkill burden concentrates collision risk on threatened species in low- and middle-income countries
TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway
Plasma proteomic profiles of Alzheimer’s disease and neurodegeneration in African cohorts
Abstract Alzheimer’s disease and related dementia (ADRD) represents a growing public health burden, especially in low- and middle-income countries. Yet, most studies focus on Non-His...
Coexistence of percolative and quantum-confined charge orders in marginally twisted TiSe2/NbSe2 heterostructure
Radical-omics reveals the hydrogen-abstraction pathway of isoprene oxidation
Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation
Abstract Mitochondria remain at the core of cell metabolism, whereas the nucleus integrates cellular and environmental signals to activate genes. However, the mechanisms that directl...
Chlorinated VSLSs Surpass HCFCs in CFC-11-Equivalent Emissions for Ozone Layer Depletion in China
Few-atom-thick silver films for enhanced nanoscale nonlinear optics
Abstract The inherently weak nonlinear optical response of bulk materials remains a fundamental limitation in advancing photonic technologies. Nanophotonics addresses this challenge...
Dual activation of NLRP3 and pyrin inflammasomes mediates host responses to the human fungal pathogen Coccidioides
Abstract Coccidioides is a dimorphic fungal pathogen that grows as a mold in soil and produces infectious arthroconidia. Inhaled arthroconidi...