Plasma proteomic profiles of Alzheimer’s disease and neurodegeneration in African cohorts
Abstract
Abstract Alzheimer’s disease and related dementia (ADRD) represents a growing public health burden, especially in low- and middle-income countries. Yet, most studies focus on Non-Hispanic white (NHW) populations from high-income countries. This study investigates plasma proteomic signatures associated with amyloid pathology in African populations. Nigerian older adults from the VALIANT study and participants from a Tanzanian study, with available biomarker quantification in plasma are employed. For proteomic comparison, participants from the Canadian TRIAD cohort are included, capturing a distinct population. Here, we show that multiple proteins are differentially abundant in the plasma of p-tau217-positive individuals and in the different cognitive groups, with findings largely consistent amongst African cohorts. Comorbidities are significantly associated with protein levels and differences in plasma biomarkers levels are found between sexes. Lastly, VALIANT and TRIAD show both shared and unique protein profiles in relation to amyloid-pathology. These findings support the utility of fluid biomarkers in ADRD in African populations.
Article Details
Authors (38)
Ilaria Pola
Tolulope Akinyemi
Kübra Tan
Oladotun Olalusi
Wiebke Traichel
Giulia Giacomucci
Joseph Yaria
Nesrine Rahmouni
Gabriel Ogunde
Olabode Oguntiloye
Arthur C. Macedo
Ayotomiwa Fagbemi
Eniola Cadmus
Joseph Therriault
Femi Popoola
Stella-Maria Paddick
Catherine Dotchin
Alyoce Kisoli
Richard Walker
Mayowa Ogunronbi
Dorcas Olujobi
Olaoluwa Famuyiwa
Joshua Akinyemi
Mayowa Owolabi
Chinedu T. Udeh–Momoh
Olusola Ladokun
Anthony Griswold
Roman Romero-Ortuno
Margaret Pericak-Vance
Adesola Ogunniyi
Stephanie Debette
Brian Lawlor
Nicholas J. Ashton
Rajesh Kalaria
Henrik Zetterberg
Pedro Rosa-Neto
Rufus O. Akinyemi
Andrea L. Benedet