Journal of Clinical Oncology
Articles in this Issue
Enhancing access to breast cancer clinical trials with breastcancertrials.org and a dedicated clinical trial navigation program.
e13506 Background: Despite the crucial role that breast cancer clinical trials play in advancing treatments, many patients are unaware of available opport...
SHR-A1811 in HER2-expressing salivary gland cancers: Preliminary efficacy and safety results.
6006 Background: Salivary gland cancer (SGC) is a rare and heterogeneous malignancy with limited treatment options in adva...
Opioid use disorder among females with breast cancer: A comprehensive analysis of prevalence in the United States and associated factors.
1118 Background: Patients with breast cancer (BC) are frequently prescribed opioids for pain management, placing them at risk of opioid use disorder (OUD)...
Stereotactic radiotherapy plus immunotherapy and influence on prognosis in driver-gene–negative non-small cell lung cancer patients with brain oligo-metastases.
2614 Background: This study seeks to elucidate the therapeutic benefits of integrating stereotactic radiotherapy (SRT) with immunotherapy for treating bra...
Trends and disparities in renal failure and multiple myeloma–related mortality among adults aged 55 and above in the United States from 1999–2020: A CDC-WONDER analysis.
e19567 Background: At diagnosis, around 20% of patients with multiple myeloma (MM) have impaired renal function. Renal failure (RF) is the leading cause o...
Molecular profiling of body fluid cfDNA: Advancing diagnostics and therapeutic decisions.
3054 Background: Effusions in cancer patients pose several critical challenges for clinicians. In known cancer patients, an effusion may signal recurrence...
Association of AI-informed biomarkers of spatial organization of tumor-infiltrating lymphocytes with loco-regional recurrence in laryngeal squamous cell cancer.
6073 Background: Laryngeal Squamous Cell Carcinoma (LaSCC) has varying outcomes based on the stage of cancer patients present with. Currently, a high prop...
Effect of emerin dysregulation on the very-small-nuclear phenotype and lineage plasticity associated with a clinically aggressive subtype of prostate cancer.
e17038 Background: Circulating tumor cells (CTCs) with a very-small-nuclear (vsn) phenotype (i.e., vsnCTCs) in prostate cancer (PCa) represent a distinct...
Computational pathology to predict docetaxel benefit in patients with metastatic hormone-sensitive prostate cancer from the CHAARTED trial (ECOG-ACRIN E3805).
1560 Background: The CHAARTED trial demonstrated the efficacy of early docetaxel (DTX) in combination with androgen deprivation therapy (ADT) for metastat...
Clinical outcomes in patients with mismatch repair-deficient colorectal cancer: A retrospective real-world evaluation in a single tertiary cancer centre.
e23301 Background: Approximately 15% of all patients (pts) with colorectal cancer (CRC) harbour mismatch repair deficiency (dMMR). Although the advent of...
Safety and preliminary efficacy from a phase 1 study of INCB123667, a selective CDK2 inhibitor, in patients with advanced platinum-resistant and refractory ovarian cancer (OC).
5514 Background: Inhibition of cyclin-dependent kinase 2 (CDK2), the binding partner of cyclin E1 (CCNE1), is a potential therapeutic approach for cancers...
Exploring clonal hematopoiesis (CH) of short variants (SVs) detected in liquid biopsies (LBx) in genes relevant to non-small cell lung cancer (NSCLC).
e20675 Background: Clonal hematopoiesis (CH) results from fitness-enhancing mutations in hematopoietic stem cells. Although many CH SVs are in heme-relate...
Combining novel miRNA biomarkers with CA19-9 to enhance early detection of pancreatic ductal adenocarcinoma.
e16443 Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with a 5-year relative...
Trends in survival, mortality determinants, and demographic factors in pancreatic carcinoma: An analysis from 2000 to 2021.
e16434 Background: Pancreatic carcinoma is among the deadliest malignancies, with persistently low survival rates and significant disparities in outcomes...
Safety and efficacy of HAIC or lenvatinib combined with sintilimab as neoadjuvant therapy for high recurrence risk resectable stage IB solitary hepatocellular carcinoma: A prospective, randomized, two-cohort, exploratory phase II clinical study.
e16288 Background: PD-1/PD-L1 inhibitors combined with targeted agents or HAIC (Hepatic Arterial Infusion Chemotherapy) can reduce the burden of micrometa...
Treatment patterns in HR+/HER2- metastatic breast cancer (MBC) with co-occurring <i>PIK3CA</i> and <i>ESR1</i> mutations.
1082 Background: PIK3CA and ESR1 mutations co-occur in 12-15% of patients with HR+/HER2- MBC. While FDA-approved PI3K...
Racial disparity in the incidence and mortality of young adults with breast cancer: A nationwide study.
e13804 Background: Breast cancer (BC) remains the most diagnosed malignancy among adolescent and young adult (AYA) females, with a steadily increasing inc...
The EQUAL study: Utilizing plasma EGFR cfDNA detection as an accessible screening tool for lung cancer in underserved patients ineligible for routine screening.
TPS3168 Background: Lung cancer (LC) among non-tobacco-users is increasing in the United States, with no routine screening available. Among those patients...
Exploring molecular resistance mechanisms in therapy naïve NSCLC patients: A retrospective 2 year Indian study.
e15074 Background: We hereby present the meta analysis from molecular profiling of NSCLC patients treated at our centre over the past 2 years. NSCLC accou...
Longitudinal analysis of incidence, mortality, and survival trends in acute lymphoblastic leukemia: A five-decade study with insights into demographic disparities from Surveillance, Epidemiology and End Results program database (1975-2021).
e18530 Background: Acute lymphoblastic Leukemia (ALL) is a rare malignancy accounting for 0.3% of all new cancer cases and 0.2% of cancer-related deaths i...
Predictive role of circulating tumor DNA in pMMR locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy combined with sintilimab.
3528 Background: Circulating tumor DNA (ctDNA) has emerged as a potential biomarker for various solid tumors, including colorectal cancer (CRC). It offers...
Major pathological response to neoadjuvant immune-related therapy and influence on long-term survival in patients with locally advanced oral squamous cell carcinoma.
6042 Background: In neoadjuvant immune-related therapy (NAIT) for patients with locally advanced oral squamous cell carcinoma (LAOSCC), it has been highly...
Recent trends in US real-world first-line (1L) treatment patterns for patients with locally advanced or metastatic urothelial carcinoma (la/mUC).
e16556 Background: Recent advances in a rapidly evolving la/mUC treatment (tx) landscape have provided more life-prolonging tx options. Real-world data ar...
Targetable mutations in cutaneous skin cancers: A comparative study across melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma.
e21555 Background: Skin cancers, including melanoma, squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and Merkel cell carcinoma (MCC), exhibit u...
Trial in progress: Evaluating the effectiveness of Blue-button—A tool for institution-agnostic, EHR-integrated regional automated clinical trial prescreening and matching.
TPS1658 Background: Clinical trial enrollment is essential for advancing cancer treatment and improving patient outcomes. Despite the benefits, only 7% of...