Journal of Clinical Oncology
Articles in this Issue
Genomic profiles and treatment outcomes in young adults with stage IV non-small cell lung cancer (NSCLC): Insights from the Middle East.
e20690 Background: NSCLCs in young adults account for less than 10% of all NSCLCs and show distinct mutational profiles compared to those in elderly patie...
Vitamin D deficiency in prostate cancer: Prevalence in a sun-rich climate and the influence of androgen deprivation therapy.
e17096 Background: Vitamin D is essential for calcium absorption, bone health, and immune function. Despite the abundant sunlight in Southern California,...
TUB-030, a novel ADC targeting 5T4: A phase I/IIa multi-center, first-in-human clinical trial (5-STAR 1-01) in patients with advanced solid tumors.
TPS3164 Background: TUB-030 is a novel antibody-drug conjugate (ADC) targeting 5T4, an oncofetal antigen expressed in vari...
Analysis of the results of intravesical perfusion therapy combined with immediate or non-immediate hematoporphyrin intravesical perfusion photodynamic therapy (PDT) after TURBT for NMIBC.
e16593 Background: NMIBC has a high postoperative recurrence rate. Therefore, Hematoporphyrin intravesical perfusion PDT being explored to reduce the recu...
Malignant giant cell tumor of bone: A case series in the denosumab era.
e23510 Background: Giant cell tumor of bone (GCTB) is a locally recurrent, rarely metastasizing tumor. However, GCTB can undergo malignant transformation....
Real world adverse events of ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy.
e19552 Background: Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy was approved by the FDA in Feb...
Astrocytoma survival patterns and key prognostic factors: A population-based study.
e14026 Background: Astrocytoma is a glioma that arises from astrocytes in the central nervous system and is classified into four grades (I-IV) based on ma...
Immune related kidney toxicity, management, and outcomes in ICI treated patients with advanced or metastatic cancers.
2601 Background: The impact of kidney immune-related adverse events (KirAEs) and their management (mgmt) on clinical outcomes in patients receiving immune...
Outcomes of metastatic esophageal and gastroesophageal junction cancers: A 13-year single-center study.
e16061 Background: The prognosis of metastatic esophageal (Eso) and gastroesophageal (GEJ) cancers is poor. However, the introduction of immunotherapy and...
A phase 2 study of response-guided neoadjuvant sacituzumab govitecan and pembrolizumab (SG/P) in patients with early-stage triple-negative breast cancer: Results from the NeoSTAR trial.
511 Background: Sacituzumab govitecan (SG) is a TROP-2 directed antibody-drug conjugate (ADC) approved for metastatic trip...
Efficacy of immune checkpoint inhibitors versus chemotherapy in metastatic urothelial carcinoma: A systematic review and meta-analysis.
e16560 Background: Metastatic urothelial carcinoma (mUC) is conventionally managed with platinum-based chemotherapy, which might be effective but is often...
Genomic newborn screening for cancer risk: A retrospective cohort study.
10014 Background: Population-based newborn screening (NBS) improves outcomes through early detection of rare pediatric conditions. Cancer is a leading cau...
Outcomes of Ph-like B-lineage acute lymphoblastic leukemia in the era of novel therapies.
6535 Background: Ph-likeALL) is a high-risk subset of B-ALL with poor treatment response and high relapse rates. We examined outcomes of Ph-like B-ALL pts...
Efficacy and safety of atezolizumab and bevacizumab with or without transarterial chemoembolization as first-line therapy for advanced hepatocellular carcinoma: An international multicenter real-world study.
4105 Background: Transarterial chemoembolization (TACE) combined with immunotherapy and targeted therapy provides a promising therapy for advanced hepatoc...
Evaluation of novel MUC1-c targeted near-infrared imaging agent for fluorescence-guided surgery of cancer.
e15072 Background: Tumor-targeted, near-infrared (NIR) fluorescent is an emerging field of real-time intraoperative imaging. Targeted NIR dyes contain NIR...
The individual and joint effects of air pollution exposure on plasma proteome among vulnerable elderly: Implications for lung cancer risk in the Cancer Prevention Study-II Nutrition Cohort.
e22576 Background: The biological mechanisms underlying air pollution-induced lung carcinogenesis remained underexplored. We assessed individual and joint...
Effect of fusion of radiomic, pathomic, and clinical biomarkers on multi-scale tumor biology and OS stratification in HNSCC receiving standard of care (SOC).
6046 Background: SOC immunotherapy (IO) for head and neck squamous cell carcinoma (HNSCC) has limited efficacy with inadeq...
Well-being Pathway (We-Path): An Italian integrative oncology community-based program for cancer survivors.
e13874 Background: Integrative oncology underlines the role of nutrition, physical activity, and healthy lifestyle habits in enhancing survival and mitiga...
Health-related quality of life (HRQoL) outcomes with darolutamide in the phase 3 ARANOTE trial.
5004 Background: Effective and well tolerated treatments to maintain HRQoL are essential for patients with metastatic hormone-sensitive prostate cancer (m...
Incidence of malignant and premalignant conditions in LGBTQIA+ individuals on gender-affirming hormone therapy: A systematic review and meta-analysis.
e22580 Background: LGBTQIA+ individuals comprise approximately 7.1% of the U.S. population. Gender-affirming hormone therapy (GAHT) is integral to transit...
Trends in gastric cancer mortality in the US: A population-based analysis, 1999-2023.
e16072 Background: Gastric cancer is a leading cause of mortality worldwide, with pronounced variations in outcomes across populations. This study investi...
HLA allele, TCR V- and J-gene segment usage combinations and their association with survival in neuroblastoma.
10042 Background: Neuroblastoma has variable outcomes across different risk groups. In children with stage 4 neuroblastoma, five-year overall remains arou...
A phase 1/2 study of vusolimogene oderparepvec (RP1) in primary melanoma (mel) to reduce the risk of sentinel lymph node (SLN) metastasis.
TPS9607 Background: The majority of 100,000 annual new U.S. cases of mel consist of localized early-stage disease that undergo wide local excision (WLE) +...
Plasma metabolomic signatures for predicting pancreatic ductal adenocarcinoma survival: The clinical application of targeted mass spectrometry lipidomics.
e16409 Background: Pancreatic ductal adenocarcinoma (PDAC) is one the most lethal human cancers with an overall 5-year survival of 12%. Diagnostic and pro...
Effect of co-occurring TP53 and intracellular proliferation pathway mutations on disease recurrence and survival benefits in head and neck cancers.
e18046 Background: Head and neck cancer (HNC) is often driven by genetic alterations, particularly co-occurring mutations in TP53 gene and key proliferati...