Journal of Clinical Oncology
Articles in this Issue
A plasma proteomics-based model for predicting response to neoadjuvant chemotherapy in ovarian cancer.
3056 Background: Neoadjuvant chemotherapy (NACT) is a standard treatment option for advanced high-grade serious ovarian cancer (HGSOC). Following interval...
Wildfire smoke, risk mitigation behaviors, and cancer risk: A community-based study.
e23152 Background: California’s San Joaquin Valley has the worst air quality in the U.S., exacerbated by hazards, such as wildfires. Wildfire smoke is ass...
Phase II trial of anti PD-1 monoclonal antibody and FOLFOXIRI combined with long-course radiotherapy as the total neoadjuvant treatment for proficient mismatch repair, locally advanced, low rectal cancer (PANFORTE).
e15621 Background: The current standard treatment for locally advanced low rectal cancer (LALRC) achieves a complete respo...
Analysis of discordance between immunochemistry of mismatch repair proteins and next generation sequence testing of microsatellite instability in gastrointestinal cancers.
e16477 Background: Microsatellite Instability (MSI) is a well-established predictive biomarker for the efficacy of immune checkpoint inhibitors. MSI-high...
Glycosylation patterns of tumor-derived small extracellular vesicles and hypoxia signatures in head and neck squamous cell carcinoma.
e18067 Background: Hypoxia characterizes solid tumors and results in increased tumor resistance. Head and neck squamous cell carcinoma (HNSCC) characteriz...
Adjuvant, neoadjuvant and surgical treatment for locally advanced cervical cancer: A network meta-analysis.
5526 Background: Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer (LACC). Alternative strategies, includ...
Google search analysis: What do people want to know about prostate cancer and where do they find answers?
e23073 Background: With over 95% of Americans online, Google has become the most utilized search engine. Google has developed machine learning technology...
Comparative efficacy and safety of CAR T-cell therapy versus standard of care for relapsed/refractory diffuse large B-cell lymphoma: A meta-analysis.
e14526 Background: Diffuse large B-cell lymphoma (DLBCL) accounts for a third of all non-Hodgkin’s lymphomas. Many cases have been reported as refractory...
Expanding access to care through sustainable replicable model of care delivery.
e13862 Background: Access to equitable care remains a major challenge. In most countries, access to specialized care is limited because of socioeconomic,...
PARPi effectiveness after CDK4/6i in <i>BRCA1</i> - and <i>BRCA2</i> -associated HR+/HER2- advanced breast cancer: Results from the multicenter real-world PAMBRACA study.
1063 Background: Poly(adenosine diphosphate–ribose) polymerase inhibitors (PARPi) are the paramount of personalized therapy for BRCA1...
The gift that keeps giving you gifts you don't want: Mixed methods analysis of financial toxicity in cutaneous T-cell lymphoma.
e23139 Background: Cutaneous T-cell lymphoma (CTCL) is treated with multimodal therapy with frequent healthcare visits and high out-of-pocket (OOP) costs....
Biologic correlates of circulating tumor DNA (ctDNA) shedding in the INTERCEPT colorectal cancer (CRC) study.
3591 Background: ctDNA is a promising tool for early cancer detection and monitoring of minimal residual disease (MRD). The relationship between vesicle t...
Investigating clinical and molecular characteristics of BRAF mutated MSS CRC and impact of inflammatory markers on survival outcomes.
e15595 Background: Approximately 8% of patients with MSS metastatic colorectal cancer (mCRC) have BRAF mutation, which is typically associated with worse...
Intelligent SERS navigation system to guide lung cancer surgery through intraoperative metabolic acidosis.
e20061 Background: Lobectomy combined with systematic lymph node dissection is the standard treatment for early stage lung cancer. However, partial resect...
Beamion PANTUMOR-1: A phase II, multicenter, multicohort, open-label trial to evaluate the efficacy and safety of the oral HER2-selective tyrosine kinase inhibitor zongertinib for the treatment of <i>HER2</i> -mutated or overexpressed/amplified solid tumors.
TPS3187 Background: While it is well known that HER2 overexpression, amplification, and mutation drives various tumors, there remains an unmet need for ef...
Racial differences in peripheral neuropathy and associated supportive treatment in breast cancer patients on platinum- and taxane-based chemotherapy regimens.
e24107 Background: Neoadjuvant and adjuvant chemotherapy for breast cancer (BC) is associated with significant side effects such as chemotherapy-induced p...
Mechanism of the synergistic enhancement of response to immunotherapy in advanced cholangiocarcinoma based on microbial immunometabolomics.
e13651 Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive liver tumor with poor prognosis, and its incidence is gradually increasing...
Marketing cancer care: A content analysis of ethical compliance in television advertising by top-ranked US cancer centers.
e23169 Background: Direct-to-consumer advertising (DTCA) in cancer care targets vulnerable patient populations and has been shown to influence treatment d...
Clinicogenomic analysis of <i>EGFR</i> -mutant lung cancers for identification of Rb inactivation as a hallmark of squamous transformation.
8606 Background: Histologic transformation to squamous carcinoma (LUSC) is a recognized mechanism of resistance in EGFR -mutant lu...
Efficacy and safety of trastuzumab deruxtecan in gastrointestinal malignancies: A systemic review and meta-analysis.
e16468 Background: Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has demonstrated efficacy in treating a variety of gastrointest...
Effects of the COVID-19 pandemic on staging and treatment patterns in non-small cell lung cancer: A large national study.
e23332 Background: The COVID-19 (C19) pandemic significantly impacted oncology care access, treatment delivery, and provider practice patterns. It was est...
A multicenter, randomized, controlled, pivotal trial of microbubble-enhanced transcranial focused ultrasound for patients with NSCLC brain metastases (LIMITLESS).
TPS2089 Background: The efficacy of systemic therapies for brain metastases (BM) is hindered by the blood-brain barrier (B...
Association of genetic predisposition to low-grade systemic inflammation with cancer-related fatigue in women receiving chemotherapy for non-metastatic breast cancer in URCC07012 and URCC10055.
556 Background: Cancer-related fatigue (CRF) is reported by ~75% of patients receiving chemotherapy for breast cancer. CRF has been linked to inflammation...
Therapeutic advantages of thymosin α1 combined with toripalimab for elderly patients with advanced melanoma: Preliminary results from a phase II study.
e21524 Background: Anti-PD-1 antibodies show limited response rates in Chinese melanoma patients, necessitating combination therapies to enhance efficacy....
Perioperative chemotherapy versus preoperative chemoradiotherapy in resectable esophageal cancer: A real-world analysis.
e16163 Background: Nonmetastatic esophageal cancer (EC) is treated with radical surgery. To improve survival rates and prevent recurrence, patients typica...