Journal of Clinical Oncology
Articles in this Issue
Real-world outcomes of immunosuppressed patients with Merkel cell carcinoma treated with immune checkpoint inhibitors.
9587 Background: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer that disproportionately affects older adults & the immun...
Development of a cfDNA-based protein-informed epigenetic signature (PEp-sig) to enable biomarker-based risk stratification for pancreatic ductal adenocarcinoma (PDA).
4149 Background: Novel blood-based biomarkers are needed for early risk stratification and personalized therapies for patients with PDA. An evidence-based...
Real-world safety and efficacy of cadonilimab mono or combination therapy in recurrent/persistent/metastatic cervical cancer in Wuxi City, China.
e17507 Background: Patients with recurrent/persistent/metastatic cervical cancer (R/P/M CC) have poor prognosis. Conventional radiotherapy and chemotherap...
Performance of a 52-gene NGS panel combined with shallow WGS for accurate HRD analysis.
e17570 Background: Homologous recombination deficiency (HRD) is a pivotal biomarker for predicting response to PARP inhibitors in multiple cancers. This s...
SHAP analysis of predictive factors for pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy.
e12527 Background: Pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) is a key predictor of long-term ou...
Use of dynamic blood flow device with conjugated affinity ligands on glass substrate to capture circulating tumor cells in cancer patients.
e15029 Background: Primary tumors are known to shed circulating tumor cells (CTCs), promoting disease in circulation and thus rendering the patient highly...
Efficacy and safety of nivolumab plus ipilimumab for patients with pre-treated type B3 thymoma and thymic carcinoma: Results from the EORTC-ETOP NIVOTHYM phase II trial.
8016 Background: Thymic malignancies represent a therapeutic challenge in the advanced, metastatic setting, with limited options after the failure of plat...
Outcomes of immunotherapy in hormone receptor–positive breast cancer: A systematic review and meta-analysis.
e13094 Background: Immunotherapy offers a promising approach for triple negative breast cancer; however, its effectiveness and safety remain uncertain in...
Initial results of a screening trial for evaluating oncogenic drivers in Japanese patients with surgically resected early-stage non-small cell lung cancer: LC-SCRUM-Advantage.
8065 Background: The LC-SCRUM-Advantage is a screening trial to evaluate oncogenic drivers in patients with surgically resected early-stage non-small cell...
Factors associated with immunotherapy response for hepatocellular carcinoma.
4106 Background: Immunotherapy has shown remarkable progress in treating hepatocellular carcinoma (HCC) in recent years. We aim to investigate the clinica...
Effects of Yijing Buqi Yangxue prescription on the proliferation and related signal transduction of esophageal cancer cells by activating T cells.
e16122 Background: Esophageal cancer is a malignant disease that seriously threatens human health. This study aims to screen out the effective Chinese her...
Predicting colorectal cancer patient response to neoadjuvant chemotherapy using the MicroOrganoSphere (MOS) platform.
e15518 Background: Neoadjuvant therapy is a critical component of curative treatment strategies for advanced-stage colorectal cancer (CRC). In this settin...
Evaluating the impact of COPD exacerbations on survival outcomes in non-small cell lung cancer patients receiving immunotherapy: A retrospective cohort analysis.
e20613 Background: Advances in immunotherapy have changed the treatment landscape for advanced non-small cell lung cancer (NSCLC). Recent studies suggest...
The efficacy of daprodustat compared to standard recombinant human erythropoietin (rhEPO) in treating anemia among patients undergoing dialysis: A systematic review and meta-analysis.
e23316 Background: Daprodustat, a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, prevents the degradation of HIF and promotes erythropoi...
Subgroup analysis by fitness criteria of patients (pts) with blastic plasmacytoid dendritic cell neoplasm (BPDCN) treated with first-line (1L) tagraxofusp (TAG).
6531 Background: BPDCN, an aggressive orphan hematologic neoplasm, expresses CD123 and presents in skin, bone marrow, blood, and viscera. For pts eligible...
An open-label, phase 1 trial with expansion cohort of botensilimab (AGEN1181) + balstilimab (AGEN2034) + nab-paclitaxel + gemcitabine + cisplatin + chloroquine + celecoxib in adult patients with previously untreated metastatic pancreatic cancer.
TPS4234 Background: The unfolded protein response (UPR) is an adaptive endoplasmic reticulum (ER) stress pathway that and can prevent cellular death under...
Successful accrual of a cluster randomized controlled trial (RCT) comparing an educationally enhanced genomic tumor board (EGTB) intervention to usual practice (S2108CD, NCT# 05455606).
1544 Background: Observational studies show genomic tumor boards (GTBs) can enhance clinician knowledge and application of genomic tumor test (GTT) result...
Ultrasensitive circulating tumor DNA (ctDNA) detection for prognostication in triple-negative breast cancer (TNBC) post-neoadjuvant chemotherapy (NAC).
552 Background: NAC +/- immune checkpoint inhibitors is the standard of care for most early-stage TNBC patients. After NAC and breast surgery, adjuvant tr...
Prediction of lung cancer development using chest X ray with microRNA samples in health screening of patients.
e22606 Background: Chest X ray (CXR) has been the most common screen test procedure for detection of lung cancer. Lung cancer progresses rapidly and a sin...
Novel potent and selective fourth-generation inhibitors targeting EGFR for NSCLC therapy.
8622 Background: Epidermal growth factor receptor (EGFR)-activating mutations (Del19 or L858R) are oncogenic drivers of non-small cell lung cancer (NSCLC)...
Effect of irradiation on the killing effect of NK cells in colon cancer through MYB/TIM3 axis.
3133 Background: Natural killer (NK) cells play a crucial role in tumor progression and anti-tumor immunity. However, they often exhibit an exhausted phen...
Generative artificial intelligence (AI) for predictive analysis: Can AI estimate the likelihood of sentinel lymph node metastases in early-stage breast cancer?
e23133 Background: Generative AI model o1 has potential to compile relevant information from pathology and radiology reports, facilitating medical record...
Effect of ivosidenib and vorasidenib on 2-hydroxyglutarate levels in low grade glioma: An in vivo MR spectroscopy study.
2081 Background: IDH-mutant gliomas are slow-growing infiltrating tumors of astrocytic (AS) or oligodendroglial (OG) origin (WHO grade 2/3). The mutations...
Phase I study of mitoxantrone hydrochloride liposome in relapsed and refractory pediatric tumors.
10049 Background: Compared with solvent-based mitoxantrone, mitoxantrone hydrochloride liposome has been found to reduce bone marrow toxicity. This open-l...
Extranodal MALT lymphoma: A retrospective survival analysis study from SEER database.
e19043 Background: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), commonly referred to as extranodal MALT lymphoma, is an...