Journal of Clinical Oncology
Articles in this Issue
A multicenter randomized phase II trial assessing the efficacy and safety of mCapOX plus cetuximab and mFOLFOX6 plus cetuximab as first-line treatment for patients with RAS/BRAF wild-type metastatic colorectal cancer: Primary results of the CAPCET study.
3563 Background: This CAPCET randomized phase II trial was designed to assess the efficacy and safety of modified capecitabine and oxaliplatin (mCapOX) pl...
The impact of dietary factors on esophageal cancer over three decades: A global epidemiological overview.
e16155 Background: Esophageal cancer remains a major global health concern due to its high mortality and disability burden. Dietary risk factors, such as...
Efficacy and safety of regorafenib combination with PD-1 inhibitors vs. regorafenib monotherapy in second-line treatment for patients with unresectable hepatocellular carcinoma after failure of different first-line treatments: A multicenter retrospective real-world study.
4088 Background: Regorafenib is the first oral targeted drug as a second-line agent in patients with unresectable hepatocellular carcinoma (HCC) who progr...
Validation of a study design that promotes diversity in clinical trials.
e23000 Background: Diversity and inclusivity in clinical trials are important for generating well-balanced biomedical data for analysis. The ongoing, mult...
Impact of in vitro fertilization on malignant transformation of endometriotic cysts: A retrospective cohort analysis of endometriosis-associated ovarian cancers.
e17581 Background: Endometriosis, affecting 10% of reproductive-aged women, carries a 1–3% lifetime risk of malignant transformation, predominantly to cle...
Impact of a collaborative care-based symptom intervention model on chemotherapy adherence in patients with breast cancer.
1543 Background: Treatment toxicity may limit the ability of cancer patients to receive all recommended cycles of therapy. Four to six cycles of docetaxel...
Improving infusion therapy management in metastatic breast cancer: Real-world pilot study of a new pharmacy resource.
e13115 Background: Infusion-based therapies are integral to the treatment of metastatic breast cancer. However, their management requires complex coordina...
Phase 1 study of the anti–immunoglobulin-like transcript 3 (ILT3) monoclonal antibody (mAb) MK-0482 + pembrolizumab (pembro) + paclitaxel for previously untreated advanced triple negative breast cancer (TNBC).
e13135 Background: First-line treatment for advanced TNBC with PD-L1 CPS ≥10 is chemotherapy plus pembro. ILT3 is an inhibitory receptor expressed on mono...
Co-designing a smartphone-based navigation system for cancer patients.
e13727 Background: Kentucky ranks 1st among states for the worst overall cancer incidence and mortality in the U.S., with...
Conversion therapy for initially unresectable intrahepatic cholangiocarcinoma: A multicenter real-world study.
4118 Background: Currently, studies on conversion therapy for intrahepatic cholangiocarcinoma (ICC) are relatively limited. Effectiveness and optimization...
Neoadjuvant chemoimmunotherapy with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-2): An open-label, single-arm, phase 2 study.
6069 Background: Neoadjuvant chemoimmunotherapy has been an emerging hotspot for the treatment of locally advanced head and neck squamous cell carcinoma (...
Gender disparities in major adverse cardiovascular and cerebrovascular events among liver cancer patients: A nationwide analysis (NIS 2016–2021).
e16271 Background: Liver cancer poses a major global health burden, with gender differences influencing outcomes & cardiovascular risks. This study ex...
Association of enrichment of CD7⁺CXCR3⁺ CAR T cells in infusion products with remission in relapsed or refractory diffuse large B-cell lymphoma.
7020 Background: Chimeric antigen receptor (CAR) T-cell therapy is the standard of care for relapsed or refractory diffuse large B-cell lymphoma (R/R DLBC...
Epidemiological analysis of gastric cancer in Uzbekistan.
e13673 Background: Gastric cancer (GC) represents a significant public health concern, ranking among the leading causes of morbidity and mortality globall...
Dosing decitabine and venetoclax for terminal differentiation to improve outcomes in TP53 mutant MDS and AML.
6514 Background: Mutations in the tumor suppressor TP53 gene are common in elderly patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia...
Influence of pre-existing autoimmune disease on outcomes in patients treated with CD-19 targeting CAR-t cell therapy for lymphoma: A retrospective propensity score matched study utilizing TriNetX.
7033 Background: There is a lack of studies in the literature about the impact of baseline autoimmune diseases (AD) on outcomes in patients with lymphoma...
A randomized, controlled pilot trial of a neuromodulatory digital therapeutic for individuals with breast cancer.
1579 Background: Fatigue, pain, and mood symptoms are common side effects of cancer therapy and cancer patients. Frontoparietal circuitry has been implica...
NF1- and non-NF1–associated malignant peripheral nerve sheath tumors (MPNST): The University of Texas MD Anderson (MDACC) experience.
11576 Background: MPNSTs are aggressive sarcomas with poor prognosis due to their high propensity for metastasis, rapid growth and limited response to sta...
De-escalation of axillary surgery in breast cancer patients with 1-2 positive sentinel nodes after neoadjuvant systemic therapy.
e12612 Background: Axillary lymph node dissection (ALND) is the standard treatment for patients with tumor-positive sentinel nodes after neoadjuvant syste...
Change in practice patterns over time for endocrine therapy (ET) and radiation therapy (RT) in women with breast cancer age 65 and older.
e12574 Background: In 2016, the American College of Surgeons (ACS) recommended omitting RT for women over age 70 with stage 1, HR+ breast cancer after lum...
Effectiveness of alternating magnetic field therapy on quality of life among cancer survivors with chemotherapy-induced peripheral neuropathy: Insights of SMILE study.
12034 Background: Chemotherapy-induced peripheral neuropathy (CIPN) reduces patients' quality of life (QoL) due to consistent sensory and motor disturbanc...
Circulating tumor DNA concentrations and blood tumor mutation burden as biomarkers of outcomes in a phase 1 study of select advanced solid tumors.
e14550 Background: Circulating tumor DNA (ctDNA) and tumor mutation burden (TMB) have demonstrated value as biomarkers of response in oncology clinical tr...
Re-evaluation of HER2 status and prognostic implications of ultra-low and low HER2 expression in estrogen receptor–positive breast cancer.
e12546 Background: Recent studies have shown antibody-drug conjugates' efficacy in HER2-low breast cancer, but the classification and clinical significanc...
ctDNA-guided adjuvant radiation for patients with HPV-related oropharyngeal cancer: First planned interim analysis of a phase II multisite study.
e18080 Background: Patients with early-stage HPV-related oropharyngeal squamous cell carcinoma (HPV-OPSCC) have favorable outcomes when treated with trans...
Augmenting clinician workflow to enable delivery of guideline concordant cancer care with an LLM-based system.
e13702 Background: Applying Large Language Models (LLMs) to multifactorial data for patients with cancer may facilitate guideline-concordant care delivery...