Journal of Clinical Oncology
Articles in this Issue
Impact of AI-augmented histopathology review on next-generation sequencing (NGS) success.
1618 Background: Insufficient nucleic acid quantity (QNS) can compromise NGS success (QNS rates can be >20%), necessita...
Risk of lung cancer in systemic lupus erythematosus patients with interstitial lung disease: A retrospective cohort study.
e20088 Background: Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease that may affect virtua...
Beyond the tumor: Cardiovascular mortality in female ovarian cancer patients—A retrospective analysis of the last 2 decades (1999-2020).
e17594 Background: Cardiovascular disease (CVD) is the leading cause of death among women with ovarian cancer. This study...
Comparative clinical outcomes with lenvatinib versus cabozantinib post-progression on first-line immunotherapy in patients with advanced hepatocellular carcinoma.
e16246 Background: First line systemic therapy for advanced hepatocellular carcinoma (HCC) includes immune checkpoint inhi...
1L olomorasib plus pembrolizumab +/- chemotherapy in <i>KRAS</i> G12C-mutant NSCLC patients +/- a prior cycle of SOC: Results from LOXO-RAS 20001 and SUNRAY-01.
8570 Background: Real-world data suggests allowing 1 cycle of standard of care (SOC) prior to enrollment into first-line (...
A phase 1 trial of the oncolytic virus SVV-001 with nivolumab and ipilimumab in patients with high-grade neuroendocrine neoplasms.
TPS2700 Background: Poorly differentiated neuroendocrine carcinomas (NECs), including small cell and large cell neuroendoc...
First-line serplulimab for locally advanced or metastatic squamous non–small cell lung cancer: Updated survival from the ASTRUM-004R trial.
8581 Background: Although the ASTRUM-004 trial has confirmed that serplulimab plus platinum-based therapy improves surviva...
A phase II trial of a FAK inhibitor combined with albumin-bound paclitaxel and an anti–PD-1/CTLA-4 bispecific antibody for metastatic, recurrent, or persistent gastric-type endocervical adenocarcinoma (GIFT Study).
TPS5630 Background: Gastric-type endocervical adenocarcinoma (GAC) is a rare, HPV-independent subtype of cervical cancer w...
Global economic impact of modifiable risk factors in colorectal cancer: A comprehensive analysis using GBD 2023 across 189 countries.
e15740 Background: Colorectal cancer (CRC) generates major healthcare expenditures worldwide. Leveraging Global Burden of...
Reporting of occupational mesothelioma in Brazil (2007-2024): A comparative analysis between clinical registries and official occupational notification.
e23205 Background: Mesothelioma is the primary sentinel cancer for asbestos exposure. Despite its well-known etiology, it...
Impact of age on breast cancer outcomes in the neoadjuvant I-SPY2 trial.
592 Background: Historically, young women with early-stage breast cancer (EBC) have had worse outcomes than older women. T...
Trends and disparities in cancer mortality among individuals with substance use disorder in the United States, 1999-2020.
e22602 Background: Cancer mortality in the United States has declined over the past two decades, reflecting advances in pr...
Integration of individual sEV with single-cell analysis to reveal association of immune cell subsets with chemotherapy response in breast cancer.
e13114 Background: Small extracellular vesicles (sEVs) released by cancer cells directly interact with various immune cell...
Impact of geographic distance from transplant center on the risk of severe graft-versus-host disease after allogeneic hematopoietic cell transplantation.
e23055 Background: Geographic distance to care has been associated with outcomes in solid tumors, reflecting differences i...
LLC cell lines’ response and resistance to KRAS G12C inhibitors.
e20710 Background: KRAS G12C mutations define a therapeutically targetable subset of non–small cell lung cancer (NSCLC); h...
Efficient machine learning for pulmonary nodule classification on computed tomography: A lightweight multilayer perceptron approach with global radiologist validation.
e20021 Background: Lung cancer remains the leading cause of cancer mortality worldwide. Pulmonary nodules detected on Comp...
<i>ATM</i> mutations in pancreatic cancer: A real-world analysis of molecular landscapes, clinical heterogeneity, and prognostic impact.
e16376 Background: ATM is a core DNA damage repair gene. Its mutations occur in 2%-8% of pancreatic cancers, but the heter...
CLERAD-PROBE: Dosimetric analysis of I-124 PET–guided remnant radioiodine ablation in differentiated thyroid carcinoma.
3068 Background: The role of adjuvant radioiodine therapy (RIT) in differentiated thyroid carcinoma (DTC) remains controve...
National trends and in-hospital outcomes of intracoronary imaging during percutaneous coronary intervention in patients with active malignancy: A National Inpatient Sample analysis.
e13700 Background: Intracoronary imaging–guided percutaneous coronary intervention (PCI) improves procedural outcomes in t...
An integrated multidisciplinary analysis of pre-treatment cachexia in locally advanced non–small cell lung cancer.
8040 Background: Cancer-associated cachexia is underdiagnosed and not routinely captured in cancer registries, despite its...
Association of immune checkpoint inhibitor administration timing with toxicity and survival in uterine cancer: A real-world analysis.
e17640 Background: Evolving data suggest the time of day (ToD) of immune checkpoint inhibitor (ICI) administration may inf...
Cell-free DNA fragmentomics and methylomics for thymic epithelial tumors.
8118 Background: Development of circulating cell-free (cf) DNA assays for cancer detection and monitoring is an area of ac...
Beyond-line immunotherapy in ES-SCLC: Efficacy and safety of second-line PD-1/PD-L1 inhibitors after progression on first-line PD-1/PD-L1 inhibitors plus platinum-etoposide chemotherapy.
e20149 Background: While Programmed Death-1/Programmed Death-Ligand 1(PD-1/PD-L1) inhibitors combined with platinum-etopos...
Therapeutically targetable mutation changes in lung adenocarcinoma metastasis.
e20719 Background: Use of targeted therapies was reported to contribute to the sharp decline of annual mortality from NSCL...
Utility of hemoglobin A1c and blood glucose monitoring for early detection of pancreatic cancer in a high-risk cohort.
e16466 Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis largely due to late-stage diagnosis, even...