Journal of Clinical Oncology
Articles in this Issue
HRS-5041, an androgen receptor degrader, in metastatic castration-resistant prostate cancer: A phase 1, multicenter, first-in-human study.
3112 Background: ADT plus NHA have been approved for PC of different stages. However, patients (pts) inevitably develop dr...
Prior authorization utilization, administrative burden, and implications for timely care.
e23035 Background: U.S. payers widely use prior authorization (PA) to manage utilization of high-cost therapies. Although...
Neoadjuvant versus adjuvant chemotherapy for resectable high-grade soft tissue sarcoma: A real-world propensity-matched survival analysis.
11585 Background: High-grade soft tissue sarcomas are aggressive malignancies for which complete surgical resection remain...
Temporal trends in adherence to adjuvant endocrine therapy across age groups in hormone receptor–positive breast cancer.
634 Background: Adjuvant endocrine therapy (ET) reduces recurrence and mortality in hormone receptor–positive breast cance...
Electrolyte abnormalities and arrhythmia-associated inpatient deterioration in hospitalized cancer patients: National patterns in the National Inpatient Sample, 2018–2022.
e23162 Background: Electrolyte abnormalities are frequent during cancer hospitalizations, but their independent associatio...
Neoadjuvant immunotherapy combined with radiochemotherapy vs chemotherapy alone in pMMR colon cancers: The TORCH-C randomized phase 2 clinical trial.
3634 Background: The prognosis for locally advanced colon cancer (LACC) with bulky nodal disease and/or clinically T4 stag...
The influence of exercise on the mediational relationship between chemotherapy-induced sensory neuropathy and cancer-related fatigue: A nationwide phase II RCT in 111 patients receiving chemotherapy.
12151 Background: Cancer-related fatigue (CRF) and chemotherapy-induced sensory neuropathy (e.g., numbness, tingling, and...
Oncologic equivalence of brand-name vs generic imatinib in neoadjuvant <i>KIT</i> exon 11 GIST: A real-world international cohort study.
11535 Background: Neoadjuvant imatinib is routinely used to facilitate resection of localized gastrointestinal stromal tum...
Fatty acid degradation (FAD)–guided comprehensive therapy for unresectable hepatocellular carcinoma: A prospective phase II study (FAD-HCC-01).
TPS4256 Background: Hepatocellular carcinoma (HCC) exhibits marked molecular and metabolic heterogeneity, leading to varia...
Association of healthcare delivery model with stage at diagnosis of pancreatic cancer.
e23126 Background: Pancreatic cancer is a leading cause of cancer mortality in the U.S., with a 5-year relative survival r...
A phase 1/2 first-in-human study of TH9619 in patients with advanced refractory solid tumors (ODIN).
TPS3165 Background: TH9619 is a first-in-class, potent, small-molecule, and dual inhibitor of methylene-tetrahydrofolate d...
A deep-learning model for immunotherapy efficacy prediction directly from H&E slides in head-neck squamous cell carcinoma (HNSCC).
e18006 Background: Immunotherapy (IO) has emerged as the standard of care for recurrent and metastatic HNSCC. However, con...
Prevalence and risk of anemia and iron deficiency anemia in premenopausal women with breast cancer: A single-center retrospective study.
e24166 Background: Anemia is common in breast cancer patients at diagnosis and during treatment. It has been associated wi...
Trends and in-hospital outcomes of multiple myeloma in autoimmune rheumatic disease hospitalizations: A National Inpatient Sample analysis, 2016–2022.
e19577 Background: Multiple myeloma (MM) is associated with immune dysregulation and substantial inpatient morbidity. Auto...
From SMARCA4 deficiency to tumor-agnostic therapies: A single-center retrospective study for 66 patients with SMARCA4-deficient tumors.
e15206 Background: SMARCA4-deficient tumors represent a newly defined category of malignancies in recent years, characteri...
Aspirin use and outcomes with immune checkpoint inhibitors in metastatic cancer.
e14584 Background: Aspirin (ASA) may modulate antitumor immunity. We evaluated the association between concomitant ASA use...
Genomic clonality analysis of patients with metastatic lung-limited non–small cell lung carcinoma (NSCLC) who underwent double lung transplantation (DLT) across timepoints and tumor region.
8658 Background: Double lung transplantation (DLT) registry aimed for lung-limited malignancies (DREAM) study (NCT05671887...
Publication pathways and impact metrics of African cancer research presented at major international conferences.
e23391 Background: Despite bearing a disproportionate share of the global cancer burden, African researchers remain under-...
Intra-arterial chemotherapy for retinoblastoma: Treatment outcomes and globe preservation—A tertiary cancer center experience in India.
e12622 Background: Intra-arterial chemotherapy (IAC) represents an important globe-preserving strategy for advanced retino...
Phase II study of liposomal irinotecan in combination with cisplatin and bevacizumab for high-grade recurrent glioma.
e14059 Background: For patients with high-grade glioma, the most common and aggressive primary brain tumor in adults, dise...
Different roles of SALL4 and OCT3/4 in the development and evolving processes of benign and malignant germ cells.
e17006 Background: In gonadogenesis, OCT3/4 and SALL4 are expressed in early germ cells and are critical for maintaining t...
Genotype-directed targeted therapy combined with HAIC and tislelizumab for microsatellite-stable colorectal cancer liver metastasis refractory to multiple-line systemic therapy (proof-of-concept SALVLIVE trial): An interim analysis.
e15545 Background: The prognosis of microsatellite-stable (MSS) colorectal cancer liver metastasis (CRCLM) refractory to s...
ADELA: A double-blind, placebo-controlled, randomized phase 3 trial of elacestrant (Ela) + everolimus (EVE) versus elacestrant + placebo in ER+/HER2− advanced breast cancer (aBC) patients with <i>ESR1</i> -mutated tumors progressing on endocrine therapy (ET) + CDK4/6i.
TPS1154 Background: ET+CDK4/6i is the standard-of-care (SOC) in 1L ER+/HER2- aBC; however, tumors eventually develop resis...
Impact of volunteer-integrated palliative home visits on psychological well-being among metastatic breast cancer patients in northern Malaysia.
12090 Background: Metastatic breast cancer patients face overlooked psychosocial challenges, mitigated through home visits...
Insights through the renal lens: Clinical outcomes of newly diagnosed multiple myeloma patients with and without renal impairment in a resource-limited setting.
e19531 Background: Renal impairment (RI) is a frequent and clinically significant complication of newly diagnosed multiple...