Journal of Clinical Oncology
Articles in this Issue
The value of tumor deposits in prognosis evaluation and clinical stage optimization of colorectal cancer: A real-world population-based retrospective cohort study.
3642 Background: The location and weight of tumor deposit (TD) in the TNM staging system may be seriously underestimated,...
Efficacy and safety of non-covalent BTK inhibitors: A systematic review focused on indolent lymphomas.
e19081 Background: Covalent Bruton’s tyrosine kinase inhibitors (cBTKi) have transformed the treatment of B-cell malignanc...
Interim analysis results from Duravelo-2: Zelenectide pevedotin (zele; BT8009) + pembrolizumab in patients (pts) with previously untreated locally advanced/metastatic urothelial carcinoma (la/mUC).
4516 Background: Zele is a highly selective Bicycle Drug Conjugate (BDC) targeting Nectin-4, a protein overexpressed in la...
Updated results from the phase 2 IZALCO study: Efficacy and safety of isatuximab subcutaneous plus carfilzomib and dexamethasone in relapsed/refractory multiple myeloma.
7564 Background: In combination with conventional doublet and triplet therapy, isatuximab (Isa) provides significant benef...
Beyond <i>ESR1</i> : Multi-pathway genomic drivers of endocrine resistance in HR⁺/HER2⁻ breast cancer.
1071 Background: Endocrine resistance in HR⁺/HER2⁻ breast cancer is often associated with acquisition of...
Phase I light-dose escalation study in locally advanced pancreatic ductal adenocarcinoma: Intra-arterial (IA) padeliporfin vascular-targeted photodynamic therapy (VTP).
TPS4267 Background: Locally advanced pancreatic ductal adenocarcinoma (LA-PDAC) with > 180° vascular encasement of majo...
Real-world efficacy of nirogacestat compared to prior standard-of-care (SOC) systemic agents in desmoid tumors.
e23542 Background: Desmoid tumors are rare, locally aggressive fibroblastic neoplasms for which systemic therapy has histo...
Phase 1a/1b study of the safety, pharmacokinetics, and antitumor activity of ziftomenib in combination with imatinib in patients with advanced gastrointestinal stromal tumors (GIST) after imatinib failure.
TPS11589 Background: GIST is the most common mesenchymal neoplasm of the digestive tract and is mainly driven by gain-of-f...
Baseline dyslipidemia in treatment-naïve breast cancer: Molecular subtype–specific patterns in a large cohort.
e12692 Background: Cardiovascular disease has emerged as a major cause of long-term morbidity and mortality among breast c...
Comparative real-world safety outcomes of Pola-R-CHP versus R-CHOP in high-grade diffuse large B-cell lymphoma (DLBCL): A TriNetX study.
e19000 Background: The POLARIX trial established polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin...
Clinical associations of cannabis use among patients receiving immune checkpoint inhibitors: A real-world analysis.
11143 Background: Cannabis use is common in patients with cancer, yet its clinical associations during immune checkpoint i...
Evaluation of long-term follow-up non-respondence in a prospective study of financial toxicity of patients after radiation therapy.
e23266 Background: Barriers to enrollment and retention of socioeconomically vulnerable patients limit the diversity and g...
Phase I/II study of liposomal curcumin in combination with standard radiation and temozolomide in patients with newly diagnosed high-grade gliomas.
2069 Background: Liposomal curcumin (LC) is an intravenous formulation designed to enhance curcumin delivery and modulate...
Predictors of mechanical ventilation in metastatic cancer hospitalizations: A National Inpatient Sample study.
11044 Background: Invasive mechanical ventilation (MV) represents a major escalation of supportive care in metastatic canc...
The impact of ketogenic diet and psychological factors on tumor shrinkage in breast cancer patients receiving neoadjuvant chemotherapy: A prospective clinical trial.
e23287 Background: The response to neoadjuvant chemotherapy (NAC) in breast cancer (BC) is influenced by metabolic and psy...
A phase 1/2 study of the next-generation nectin-4–targeting antibody-drug conjugate CRB-701 (SYS6002) in patients with recurrent or metastatic head and neck squamous cell carcinoma.
6062 Background: CRB-701 is a next-generation Nectin-4–targeted monomethyl auristatin E (MMAE)-based antibody–drug conjuga...
Impact of chronic atrial fibrillation on outcomes of acute pulmonary embolism in pancreatic cancer patients.
e16368 Background: Chronic atrial fibrillation increases thromboembolic risk and may worsen outcomes in acute pulmonary em...
Tumor-agnostic and cross-indication actionable alterations in <i>IDH</i> -wildtype glioma: Precision oncology opportunities in an aggressive disease.
e14060 Background: Gliomas have few approved targeted therapies. Given frequent blood-brain-barrier disruption in gliomas,...
Phase 2 study of intratumoral oncolytic VV1 plus cemiplimab: Simon's stage 1 results from head and neck squamous cell carcinoma (HNSCC) cohort.
e18026 Background: Immune checkpoint inhibitor (ICI) therapy is part of standard of care first-line therapy for recurrent...
OMAHA-004: Phase 3 trial of the steroidogenesis inhibitor opevesostat versus androgen receptor pathway inhibitor (ARPI) switch in participants with metastatic castration-resistant prostate cancer (mCRPC) after a prior ARPI.
TPS5135 Background: Opevesostat (MK-5684; ODM-208) is an oral, nonsteroidal inhibitor of cytochrome P450 11A1 (CYP11A1), a...
Closing the depression gap in community oncology: Real-world outcomes from collaborative care.
12088 Background: Depression is prevalent among patients with cancer, yet access to evidence-based care remains uneven. Co...
Support of academic non-clinical efforts for cancer investigator faculty at Association of American Cancer Institutes.
9005 Background: Academic non-clinical time (NCT) for physician scientists (PS) and clinical investigators (CI) is critica...
Day-7 single-cell RNA sequencing of acute lung responses after 17-Gy whole-thorax irradiation in mice.
e24193 Background: Radiation pneumonitis (RP) is a clinically important toxicity of thoracic radiotherapy and can set the...
Safety and feasibility of outpatient administration of targeted alpha therapies: A systematic review and meta-analysis of radiation exposure and waste management.
e23183 Background: Targeted alpha therapies offer potent antitumor efficacy but are traditionally administered in speciali...
Factors associated with delays in treatment initiation and interruptions in head and neck squamous cell carcinoma: A retrospective single-institution analysis.
e18115 Background: Timely initiation and uninterrupted delivery of curative-intent therapy are critical in head and neck s...