Journal of Clinical Oncology
Articles in this Issue
Comparison of real-world overall survival between atezolizumab- and durvalumab-containing first-line induction and maintenance regimens in extensive-stage small cell lung cancer.
8093 Background: Both atezolizumab (atezo) and durvalumab (durva) are preferred first-line (1L) systemic treatment options...
Cognitive impairment during anti-EGFR targeted therapy in metastatic colorectal cancer patients.
12085 Background: Cognitive function is a critical determinant of psychosocial adaptation and quality of life in patients...
Oncological outcomes in post-menopausal women with Kallmann syndrome: A propensity-matched study from the Global Federated Health Network.
e23061 Background: Kallmann syndrome, a rare form of hypogonadotropic hypogonadism with anosmia, is a condition primarily...
Real-world efficacy of immune checkpoint inhibitor rechallenge in patients with advanced esophageal squamous cell carcinoma: A retrospective study.
e16046 Background: Immunotherapy combined with chemotherapy is the standard first-line (1L) treatment for advanced esophag...
Who really benefits from chemotherapy in high-risk localized soft tissue sarcoma? A virtual twin analysis of ISG-STS 1001.
11573 Background: Randomized trials of perioperative chemotherapy in high-risk localized extremity/truncal soft tissue sar...
Impact of lung cancer screening in patients diagnosed with small cell lung cancer.
8102 Background: The advent of immunotherapy significantly improved overall survival (OS) for limited-stage SCLC (LS-SCLC)...
Impact of pre-existing cancer on short-term outcomes and mortality following left ventricular assist device implantation at urban teaching centers in the United States.
e23056 Background: Cancer patients are at higher odds of various procedural complications. A recent study suggested a rise...
Integrated genomic and transcriptomic profiling of driver–pathway relationships in colorectal cancer.
e15723 Background: Relationships between DNA driver alterations and downstream transcriptional pathway activation in color...
Trends in mortality, incidence, and disability-adjusted life years of laryngeal cancer in Pakistan from 1990 to 2023: A comprehensive analysis of the Global Burden of Disease study.
e18010 Background: Laryngeal cancer remains a major cause of cancer-related mortality worldwide, particularly in low- and...
Racial disparities and nonconcordance with endocrine and HER2 therapy for breast cancer: A sequential mediation analysis of neighborhood deprivation and insurance status.
1647 Background: Racial disparities in breast cancer treatment persist, but the mechanisms driving inequities may differ b...
Clinical performance and readiness of artificial intelligence models for predicting immune-related adverse events in patients receiving immune checkpoint inhibitors: A systematic review.
e13683 Background: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently complicated by...
Closing the gap in germline testing in patients with cancer through a clinic-based awareness initiative: From booth to patient's agenda.
1603 Background: Germline genetic testing (GT) is a standard of care for a broad range of patients (pts) diagnosed with ca...
Major adverse cardiovascular events during elective chemotherapy admissions: Incidence, predictors, and in-hospital outcomes.
e24020 Background: Cardiovascular complications represent a major source of morbidity among patients receiving systemic ch...
Prophylactic vs reactive PEG tube placement in early-stage head and neck (H&N) cancer treated with curative-intent radiotherapy: Balancing benefit and burden in real-world practice.
12150 Background: Timing of Percutaneous Endoscopic Gastrostomy (PEG) placement during curative-intent radiotherapy for H&...
Comorbidities as independent predictors of mortality in lung cancer: A real-world multivariate analysis from a Latin American tertiary center with integrated molecular profiling.
e20093 Background: Lung cancer patients frequently present with multiple comorbidities that may significantly influence su...
Education, income, treatment, and survival: A retrospective cohort study of patients with breast cancer in Sao Paulo, Brazil.
e13620 Background: Socioeconomic factors influence breast cancer stage at diagnosis, access to treatment, and survival, ye...
Impact of age on immune-related toxicities and survival in non–small cell lung cancer treated with immune checkpoint inhibitors: A multicenter retrospective study.
e20641 Background: Immune checkpoint inhibitors (ICIs) are a cornerstone of therapy for non-small cell lung cancer (NSCLC)...
Caregiver professional employment and its impact on glioblastoma patient survival: Results from two prospective studies.
2050 Background: Caregiver burden is a crucial factor to consider in the diagnosis and care of patients with glioblastoma...
Risk of lung cancer among patients with idiopathic interstitial lung disease: A cohort study using All of Us research program data.
e20089 Background: Interstitial lung disease (ILD), a collection of heterogeneous conditions characterized by lung inflamm...
Real-world quality outcomes following implementation of a comprehensive care program in community oncology practice in western India.
e13575 Background: Malnutrition, psychosocial distress & impaired quality of life (QoL) adversely affect treatment tol...
A phase 1, multicenter, open-label, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of SBO-154 in subjects with advanced solid tumors.
TPS3161 Background: Mucin 1 (MUC1) is a transmembrane glycoprotein overexpressed in advanced epithelial malignancies, wher...
Effect of frailty measures on overall survival in prostate cancer: A systematic review and meta-analysis.
5077 Background: Prostate cancer at all stages is associated with a favorable prognosis and treatment is generally well to...
Association of chemotherapy with survival in node-positive penile squamous cell carcinoma stratified by nodal burden: A National Cancer Database analysis.
e17033 Background: Node-positive penile squamous cell carcinoma (PSCC) carries a poor prognosis, yet the survival benefit...
Biomarker use in subgroup analysis versus enrichment trial design as a predictor of oncology trial success.
e23122 Background: Biomarkers are widely used in oncology clinical trials for patient stratification and endpoint definiti...
Incidence, severity, and management of severe adverse events in first-line (1L) treatments for metastatic pancreatic ductal adenocarcinoma (mPDAC): A retrospective observational study.
e16377 Background: 1L systemic treatment of mPDAC can lead to severe adverse events (AEs). To contextualize the safety pro...