Journal of Clinical Oncology
Articles in this Issue
Fast-TRACKing precision oncology for rare cancers: A national decentralized trial offering comprehensive genomic profiling and a molecular tumor board.
3147 Background: The TargetCancer Foundation TCF-001 TRACK study (Target RAre Cancer Knowledge, NCT04504604) initiated on...
Sleep disorders in cancer survivors: A cross-sectional study from Morocco.
e24133 Background: Sleep disturbances are among the most frequent and burdensome symptoms in patients with cancer and ofte...
Racial representation in clinical trials supporting NCCN breast cancer guidelines: A retrospective analysis.
1651 Background: Racial disparities in breast cancer are well established, with Black women having disproportionately high...
A phase III multicenter randomized non-inferiority trial comparing selective versus modified neck dissection in node-positive oral squamous cell carcinoma (SND vs MND).
TPS6133 Background: Neck dissection is a critical component in the management of oral squamous cell carcinoma (OSCC) with...
A clinically applicable toolkit for cervical gastric-type adenocarcinoma: Diagnostic model, predictive survival nomograms, and risk stratification.
e17509 Background: Cervical gastric-type adenocarcinoma (GAS), an aggressive non-HPV-associated malignancy, is often misdi...
Trends in mortality and disparities in small intestine neoplasms among U.S. adults aged 65 years and older: A retrospective analysis of 25 years.
e15684 Background: Small intestine neoplasms are relatively rare malignancies but contribute to a growing cancer-related m...
JSKN016, a first-in-class anti-TROP2/HER3 bispecific antibody-drug conjugate (ADC), in patients (pts) with HER2-negative locally advanced or metastatic breast cancer: Results from a phase I study.
1123 Background: TROP2 and HER3 are frequently overexpressed in most of solid tumors. JSKN016 is a first-in-class bispecif...
AI-assisted systematic review and pooled analysis of anthracycline- versus taxane-based chemotherapy in advanced or metastatic angiosarcoma.
11522 Background: Comparative evidence for first-line anthracycline- (Ant) vs taxane-based (Tax) chemotherapy in advanced...
A first-in-human phase I clinical trial evaluating the safety, tolerability, and preliminary efficacy of the novel fas ligand (FasL) inhibitor M3T01 in adults with advanced solid tumors.
TPS2670 Background: Tumor-specific T cells undergo apoptotic cell death following FasL binding to the fas (CD95) receptor....
New paradigm for antibiotic selection in hard-to-treat drug-resistant infections following HSCT.
e18627 Background: HSCT patients are highly susceptible to severe infections. Conventional antimicrobial susceptibility te...
Tumor-informed versus tumor-agnostic ctDNA assays for molecular residual disease detection in colorectal cancer: A systematic review and meta-analysis.
3595 Background: Circulating tumor DNA (ctDNA) is increasingly used for detection of molecular residual disease (MRD) foll...
Impact of time-of-day (ToD) of single-agent immune-checkpoint inhibitor (ICI) on survival in advanced non–small cell lung cancer (aNSCLC) with PD-L1 ≥ 50%: Analysis of the NOTCH collaborative REAL-SAIF study.
8602 Background: There is growing evidence and interest in the role of chrono-immunotherapy. Previous studies showing bene...
Efficacy and safety of immune checkpoint inhibitor rechallenge in advanced hepatocellular carcinoma: A systematic review and meta-analysis.
e16192 Background: Immune checkpoint inhibitors (ICIs) are integral to the treatment of advanced hepatocellular carcinoma...
Multiomic profiling of early onset colorectal cancer in an irish tertiary cancer centre: Outcomes and correlative insights.
e15643 Background: Colorectal cancer (CRC) is a major global health concern as it is the second most fatal cancer worldwid...
National disparities in outcomes among hospitalizations for myelodysplastic syndromes complicated by sepsis: The impact of insurance, hospital type, and geographic region.
e18583 Background: Prior studies show that sepsis outcomes vary by insurance, hospital type, and geographic location; howe...
A phase 1b/2 study of AK130 (TIGIT/TGF-β bispecific fusion protein) combined with ivonescimab in advanced biliary tract cancer (BTC).
4142 Background: Chemotherapy (chemo) combined with or without PD-(L)1 inhibition is the standard first-line treatment for...
Efficacy and safety of TACE with or without MWA followed by sequential targeted and immunotherapy in HCC beyond the up-to-7 criteria.
e16288 Background: Although accumulating evidence suggests survival benefits of transarterial chemoembolization (TACE) com...
Efficacy and safety of PD-1 inhibitor plus chemotherapy vs chemotherapy alone in advanced gastric cancer patients with low or negative PD-L1 expression.
4041 Background: Advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma remains a major global health challen...
Intracranial activity of trastuzumab deruxtecan in HER2-low breast cancer with brain metastases: A systematic review and meta-analysis.
e13082 Background: Human epidermal growth factor receptor 2 (HER2)–low breast cancer, defined as HER2 immunohistochemistry...
ASC4FIRST wk 144 analysis: Efficacy and safety and tolerability with asciminib (ASC) vs investigator-selected tyrosine kinase inhibitors (IS TKIs) in newly diagnosed (ND) chronic myeloid leukemia in chronic phase (CML-CP).
6583 Background: In ASC4FIRST (NCT04971226) primary (wk 48) (Hochhaus A et al. N Engl J Med...
Self-reported ethnicity and outcomes of newly diagnosed multiple myeloma (NDMM) in the anti-CD38 monoclonal antibody era: A retrospective cohort study.
e19554 Background: Multiple myeloma has a well known disparity in incidence between non-Hispanic Black (NHB) and non-Hispa...
Impact of venetoclax dosing on outcomes in AML: A single-center real-world study.
e18511 Background: VIALE-A established Aza and Venetoclax (Ven) as first-line therapy (1L) for acute myeloid leukemia for...
Dietary supplement use among adult cancer survivors: Results from a large cross-sectional study in Poland.
e13782 Background: Dietary supplement use is common among adults with a history of cancer and may reflect unmet needs and...
Integrated tissue transcriptome deconvolution of grade-associated tumor microenvironment patterns in CNS tumors.
e14039 Background: Central nervous system (CNS) tumors exhibit marked tumor microenvironment (TME) heterogeneity, includin...
Intrathecal (IT) PD-1/CTLA-4 antibody combined with pemetrexed (PM) for leptomeningeal metastases (LM) from solid tumors: Preliminary results of two single-center phase I studies.
2624 Background: IT PD-1 inhibitors, alone or combined with IT PM, have shown safety and feasibility in LM from solid tumo...