Journal of Clinical Oncology
Articles in this Issue
Time-of-day administration of immunotherapy in early-stage triple-negative breast cancer: Immune-dependent chronotherapy effects in the phase III A-BRAVE trial.
1010 Background: Circadian rhythms regulate immune functions, and morning (AM) administration of immunotherapy (IO) is ass...
Impact of U.S. most-favored-nation (MFN) drug pricing on global oncology access.
11056 Background: U.S. cancer drug prices substantially exceed those in other OECD countries. In May 2025, a U.S. Presiden...
Construction and validation of a prognostic risk model for lung adenocarcinoma based on pyroptosis and necroptosis-related genes.
e20034 Background: Lung cancer is a leading cause of cancer-related deaths worldwide, and lung adenocarcinoma (LUAD) is th...
First-in-human phase I, open-label, multicenter study of HJ-004, a novel EGFR-PROTAC degrader, in patients with advanced <i>EGFR</i> -mutated non–small cell lung cancer.
TPS8678 Background: Despite remarkable progress with 1 st - to 3...
Risk of gastrointestinal (GI) immune-related adverse events (irAEs): Real-world experience.
e23410 Background: Immune checkpoint inhibitors (ICI) improve survival across solid tumors but can cause gastrointestinal...
Lisocabtagene maraleucel (liso-cel) as first-line (1L) therapy for transplant-ineligible patients (pt) with primary central nervous system lymphoma (PCNSL): The CAROLYN study.
TPS7097 Background: Treatment of PCNSL is based on high-dose methotrexate (HD-MTX) induction chemotherapy, followed by con...
Precision risk stratification for lung cancer in COPD: Evidence from the All of Us Program.
10537 Background: Chronic obstructive pulmonary disease (COPD) is a well-established independent risk factor for lung canc...
Alzheimer’s biomarkers in oncology: The impact of cancer treatment on neurodegenerative diagnostic disparities across populations.
e14048 Background: The intersection of oncology and neurodegenerative disorders has illuminated complex interactions exist...
Real-world utilization of a patient-centric symptom management guide for metastatic breast cancer.
e23403 Background: Metastatic breast cancer (MBC) and its treatments are associated with significant symptom burden that c...
Clinico-genomic landscape of Indian gallbladder cancer: Actionable alterations and opportunities for precision therapy.
e16231 Background: Gallbladder carcinomas (GBC) are the predominant biliary tract malignancies with marked geographic vari...
Comparative transcriptomic analysis of chemotherapy-naive and post-chemotherapy germ cell tumors.
5026 Background: Cisplatin-based chemotherapy is highly effective in testicular germ cell tumors (GCTs); however, the pres...
Targeted combination therapies for untreated chronic lymphocytic leukemia: A network meta-analysis of randomized trials.
7048 Background: Treatment options for previously untreated chronic lymphocytic leukemia (CLL) have expanded to include bo...
A structured patient advocacy–led communication model to improve awareness, trust, and access to oncology clinical trials in Brazil.
e13505 Background: In low- and middle-income countries (LMICs) like Brazil, participation in oncology clinical trials is h...
Real-world outcomes from 3D-PREDICT glioma chemosensitivity testing of primary CNS tumors.
2060 Background: 3D-Predict Glioma is an ex vivo chemosensitivity assay that predi...
Leveraging real-world genomic data to characterize immunotherapy response in cancers with germline <i>CHEK2</i> cancer risk variants.
e22643 Background: CHK2 is a DNA damage response (DDR) protein critical for maintaining genomic stability. Germline...
Safety and efficacy of asciminib in veterans with chronic myeloid leukemia.
6591 Background: Asciminib was approved for use in previously treated patients with chronic myeloid leukemia (CML) in 2021...
Palliative quad-shot radiation therapy in combination with low dose systemic treatment in advanced head and neck cancer.
e18024 Background: Head and neck cancer (HNC) is one of the most common cancers in Pakistan. Advanced stage is the most co...
Structured exercise program following adjuvant chemotherapy for colon cancer: A cost-utility analysis of the CHALLENGE trial.
3507 Background: The phase III CHALLENGE trial (CCTG CO.21) demonstrated improved disease-free and overall survival with a...
Timing of telepalliative care and end-of-life outcomes in advanced cancer: A multicenter retrospective cohort study.
1518 Background: Telemedicine has become an integral component of palliative care delivery; however, its impact on end-of-...
Rapid multi-task intraoperative diagnosis of lung cancer via deep neural network-driven label-free femtosecond laser imaging (FLI).
8019 Background: Rapid and accurate intraoperative pathological diagnosis is critical for guiding surgical margins and pre...
The early-onset paradox of gastric cancer: Assessment of geographic clustering, biology, treatment, and outcomes.
4088 Background: Early-onset gastric cancer (EOGC), defined as diagnosis before age 45, represents an increasingly recogni...
Incidence of colorectal cancer in renal transplant recipients compared with the general population and inflammatory bowel disease: A population-based real-world cohort study.
e15707 Background: Chronic immunosuppression following renal transplantation is associated with an increased risk of malig...
GLP-1 receptor expression in a molecularly characterized cohort of endometrial carcinoma: Results from the GEICO 163-T/SPECTRUM study.
5625 Background: The glucagon-like peptide-1 receptor (GLP-1R) plays a central role in metabolic, and hormonal signaling a...
Efficacy and safety of neoadjuvant therapy in resectable pancreatic cancer: Updated systematic review and meta-analysis of RCTs.
e16458 Background: The clinical value of neoadjuvant therapy (NAT) for resectable pancreatic ductal adenocarcinoma remains...
Nivolumab and Ipilimumab (NIVO IPI) as first-line (1L) treatment for patients with metastatic renal-cell carcinoma (mRCC): A real-world benchmarking analysis from the International mRCC Database Consortium (IMDC).
4549 Background: NIVO IPI has demonstrated durable overall survival (OS) benefit with long-term follow-up in patients with...